Results 121 to 130 of about 94,660 (301)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ALMA survey to Resolve exoKuiper belt Substructures (ARKS)

Astronomy & Astrophysics
Context. Dusty discs detected around main-sequence stars are thought to be signs of planetesimal belts in which the dust distribution is shaped by collisional and dynamical processes, including interactions with gas if present. The debris disc around the
Jankovic M. R., Pawellek N., Zander J., Löhne T., Krivov A. V., Olofsson J., Brennan A., Milli J., Bonduelle M., Wyatt M. C., Sefilian A. A., Pearce T. D., Mac Manamon S., Han Y., Marino S., Matrà L., Moór A., Booth M., Chiang E., Mansell E., Weber P., Hughes A. M., Wilner D. J., Luppe P., Zawadzki B., del Burgo C., Kóspál Á., Pérez S., Carpenter J. M., Henning T.   +29 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Production, detection, storage and release of spin currents

Beilstein Journal of Nanotechnology, 2015
Background: Quantum rings connected to ballistic circuits couple strongly to external magnetic fields if the connection is not symmetric. Moreover, properly connected rings can be used to pump currents in the wires giving raise to a number of interesting
Michele Cini
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Assessment of restrained shrinkage cracking of concrete through elliptical rings [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.An elliptical ring test method is presented to replace the circular ring test method for assessing cracking potential of concrete and other cement-based ...
Oladiran, Olayinka Gbolahan
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Reservoir Computation with Networks of Differentiating Neuron Ring Oscillators

Analytics
Reservoir computing is an approach to machine learning that leverages the dynamics of a complex system alongside a simple, often linear, machine learning model for a designated task.
Alexander Yeung, Peter DelMastro, Arjun Karuvally, Hava Siegelmann, Edward Rietman, Hananel Hazan   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source