Results 121 to 130 of about 326,335 (355)

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans [PDF]

, 2017
This is the final version of the article. Available from the publisher via the DOI in this record.Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with ...
Emond, F, Ferrucci, L, Flurkey, K, Harries, LW, Harrison, DE, Kuchel, GA, Lee, BP, Melzer, D, Peters, LL, Pilling, LC, Yuan, R   +10 more
core   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Alternative splicing at NAGNAG acceptors in Arabidopsis thaliana SR and SR-related protein-coding genes

BMC Genomics, 2008
Background Several recent studies indicate that alternative splicing in Arabidopsis and other plants is a common mechanism for post-transcriptional modulation of gene expression.
Backofen Rolf, Palusa Saiprasad G, Ali Gul, Hiller Michael, Szafranski Karol, Schindler Stefanie, Platzer Matthias, Reddy Anireddy SN   +7 more
doaj   +1 more source

Molecular Characterization of Pediatric Restrictive Cardiomyopathy from Integrative Genomics [PDF]

, 2017
Pediatric restrictive cardiomyopathy (RCM) is a genetically heterogeneous heart disease with limited therapeutic options. RCM cases are largely idiopathic; however, even within families with a known genetic cause for cardiomyopathy, there is striking ...
Hinton, Robert B., Rindler, Tara N., Salomonis, Nathan, Ware, Stephanie M.   +3 more
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Transcriptional elongation and alternative splicing

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes.
Dujardin, Gwendal, Lafaille, Celina, Petrillo, Ezequiel, Buggiano, Valeria Carmen, Gómez Acuña, Luciana Inés, Fiszbein, Ana, Godoy Herz, Micaela Amalia, Nieto Moreno, Nicolás, Muñoz, Manuel Javier, Alló, Mariano, Schor, Ignacio Esteban, Kornblihtt, Alberto Rodolfo   +11 more
openaire   +4 more sources

Genome-Wide Identification of Alternative Splicing in Botrytis cinerea During Infection Stage of Solanum lycopersicum

Microorganisms
Alternative splicing plays a crucial role in enhancing the protein diversity of eukaryotic genomes. However, alternative splicing has not been extensively studied in Botrytis cinerea.
Ping Lu, Yun Wang, Xiaoli Wang, Jiaqi Wang, Dan Wang, Haojie Shi   +5 more
doaj   +1 more source

DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model

iScience, 2022
Summary: Alternative splicing is crucial for a wide range of biological processes. However, limited by the availability of reference genomes, genome-wide patterns of alternative splicing remain unknown in most nonmodel organisms.
Lei Cao, Quanbao Zhang, Hongtao Song, Kui Lin, Erli Pang   +4 more
doaj  

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach.
Bielli, P, Calabretta, S, Capurso, G, DELLE FAVE, Gianfranco, Fendrich, V, Passacantilli, I, Pilozzi, Emanuela, Sette, C.   +7 more
core   +2 more sources