Results 141 to 150 of about 167,962 (232)

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Omics-based dissection of alternative splicing and the regulatory architecture in fungal genomes. [PDF]

Curr Res Microb Sci
Neves-da-Rocha J, Lopes MER, Santos-Saboya MJ, Azevedo MIG, Petrucelli MF, Rossi A, Martinez-Rossi NM.   +6 more
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Mechanism of alternative splicing of yeast HEH1 through competing 5' splice sites. [PDF]

Nat Commun
Banyal AK, Choudhuri P, Pillai BR, Varikkapulakkal A, Mishra SK.   +4 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Metformin improves RAN protein pathology, alternative splicing, and behavioral phenotypes in SCA8 mice. [PDF]

Life Sci Alliance
Romano LE, Tsukagoshi S, Davey-Osuch EE, Ajredini R, Manasi K, Ortiz TV, Rijos E, Bourgon NJ, Ames SE, Garrett TJ, Cleary JD, Wang ET, Ranum LP.   +12 more
europepmc   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

Alternative splicing regulates PACC1 function and promotes acidosis-induced cytotoxicity. [PDF]

Front Cell Dev Biol
Tamburro S, Gorrieri G, Callegari N, Guida F, Antonini F, Musante I, Baldassari S, Zara F, Scudieri P.   +8 more
europepmc   +1 more source

Fe‐Based Nanocrystalline Magnetic Shielding Cylinder with Subfemtotesla‐Level Magnetic Noise

Advanced Science, EarlyView.
Shields with low magnetic noise are achieved by integrating Fe‐based nanocrystalline magnetic shielding cylinders into shielding systems based on μ‐metal. Benefiting from high permeability and low loss factor, Fe‐based nanocrystalline magnetic shielding cylinders effectively suppress magnetic noise. Notably, the magnetic shielding cylinder with the ten‐
Peipei Shen, Danyue Ma, Kun Wang, Shuang Li, Yanan Gao, Pengfei Wang, FuSen Yuan, Hua Chen, Zhuo Wang, Ziling Liu, Meng Xie, Bo Li, Hongbo Zhou, Baoan Sun   +13 more
wiley   +1 more source