Results 161 to 170 of about 172,920 (260)

Role of Alternative Splicing and Polyadenylation in Regulation of Spleen Development. [PDF]

Cells
Cui J, Zhu R, Song M, Sun Y, Pang Y, Tian M, He X, Liu D, Yang X.   +8 more
europepmc   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Dysregulation of alternative splicing patterns in the ovaries of reproductively aged mice. [PDF]

Reproduction
Alsamaraee AT, Correll VL, Nyalwidhe JO, Brachova P, Alvarez NS, Alvarez NS.   +5 more
europepmc   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs. [PDF]

EMBO Mol Med
Wang W, Pan Z, Jing H, Shi R, Wu L, Wang J, Chen B, Mu J, Zhang Z, Wu T, Li Q, Shi J, Kuang Y, He L, Wang L, Sang Q.   +15 more
europepmc   +1 more source

Translational Gap in Biomarker Discovery: Tumor Surface Markers Rarely Mirror Circulating Levels

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Tumor‐associated cell surface proteins are frequently proposed as circulating biomarkers for colorectal cancer (CRC) based on their high tumor expression. However, many candidates identified through tissue‐based analyses fail to translate into clinically useful biomarkers.
Junko Mukohyama, Shohei F. Fujita, Xinyi Fu, Shigenori Suzuki, Hiroki Hamamoto, Dai Shida, Kimihiro Yamashita, Kohei Taniguchi, Sang‐Woong Lee, Akihide Yoshimi   +9 more
wiley   +1 more source

Characterization of aberrant alternative splicing landscape in patients with metastatic renal cell carcinoma. [PDF]

J Immunother Cancer
Govindarajan A, Hansen N, Mercier BD, Byron SA, Hegde A, Garcia-Mansfield K, Leskoske K, Chawla N, Meza L, Zengin Z, Barragan-Carillo R, Ebrahimi H, Castro DV, Dizman N, Hsu J, Chehrazi-Raffle A, Tripathi A, Salgia NJ, Pal SK, Pirrotte P.   +19 more
europepmc   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Phosphate starvation induces root cell-type-specific transcriptional responses and alternative splicing. [PDF]

New Phytol
González-García MP, Lanza M, Baca-González V, Bustillo-Avendaño E, Serrano-Ron L, González-Bodi S, García-Mina JM, Zamarreño ÁM, Garnica M, Moreno-Risueno MA, Caro E, Del Pozo JC.   +11 more
europepmc   +1 more source