Results 151 to 160 of about 20,789 (265)
An alternative Pit-1 RNA splicing product reveals modular binding and nonmodular transcriptional activities of the POU-specific domain. [PDF]
J W Voss+3 more
openalex +1 more source
Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu+12 more
wiley +1 more source
Coronavirus leader‐RNA‐primed transcription: An alternative mechanism to RNA splicing
Michael M. C. Lai
openalex +1 more source
Genomic structure and alternative splicing of 519, a gene expressed late after T cell activation. [PDF]
William C. Manning+3 more
openalex +1 more source
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang+18 more
wiley +1 more source
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei+4 more
wiley +1 more source
Two isoforms of human membrane-bound alpha Ig resulting from alternative mRNA splicing in the membrane segment. [PDF]
L M Yu+4 more
openalex +1 more source
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie+8 more
wiley +1 more source
Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms. [PDF]
Yuri A. Ushkaryov, Thomas C. Südhof
openalex +1 more source
A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice
OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang+9 more
wiley +1 more source