Results 181 to 190 of about 344,150 (327)

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Induced Proprioceptor and Low‐Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Advanced Science, EarlyView.
This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme, Rocio K. Finol‐Urdaneta, Jeffrey R. McArthur, Nicholas R. Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J. Adams, Mirella Dottori   +12 more
wiley   +1 more source

From protein-protein to isoform-isoform interactions: the toolkit to map alternative splicing to interactome

, 2023
Olga Tsoy, Zakaria Louadi, Chit Tong Lio, Olga V. Kalinina, Jan Baumbach, Tim Kacprowski, Markus List   +6 more
openalex   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Detection of alternative splicing: deep sequencing or deep learning? [PDF]

Brief Bioinform
Hackl LM, Neuhaus F, Ameling S, Völker U, Baumbach J, Tsoy O.   +5 more
europepmc   +1 more source

Characterization of a novel alternatively-spliced 5′ exon in the human insulin-like growth factor I (IGF-I) gene, expressed in liver and some cancers [PDF]

, 2019
Michael Wallis
openalex   +1 more source

COL3A1: Potential prognostic predictor for head and neck cancer based on immune‐microenvironment alternative splicing

, 2022
Yuchen Shen, Xinyu Li, Deming Wang, Liming Zhang, Xiao Li, Lixin Su, Xindong Fan, Xi Yang   +7 more
openalex   +1 more source

Biodegradable Adhesive Systems for Bio‐Integrated Applications

Advanced Science, EarlyView.
Biodegradable adhesives provide temporary yet reliable adhesion while degrading into safe, non‐toxic by‐products under physiological or environmental conditions. This review summarizes recent developments in physical and chemical adhesion mechanisms—including hydrogen bonding, catechol chemistry, amine‐carboxyl coupling, and emerging diazirine and urea
Won Bae Han, Sungkeun Han, Prashant Shivaji Shewale, Hyewon Cho, Li‐Hyun Kim, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +6 more
wiley   +1 more source

The implications of alternative splicing regulation for maximum lifespan. [PDF]

Nat Commun
Jiang W, Zheng S, Chen L.
europepmc   +1 more source

A novel splicing graph allows a direct comparison between exon-based and splice junction-based approaches to alternative splicing detection [PDF]

Jelard Aquino, Daniel Witoslawski, Steve Park, Jessica Holder, Amei Amei, Mira Han   +5 more
openalex   +1 more source