Results 211 to 220 of about 172,920 (260)

Alternative splicing-triggered mRNA decay informs splice-switching targets for neurodevelopmental disorders. [PDF]

J Clin Invest
Hu K, Yang R, Qiu J, Feng X, LaPre KJ, Tanouye J, Yang Y, Zhang X.   +7 more
europepmc   +1 more source

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The physiology of alternative splicing

Nature Reviews Molecular Cell Biology, 2022
Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of this complexity is reflected at the protein level and fundamentally shapes the physiology and pathology of organisms.
Luciano E Marasco, Alberto Kornblihtt, Kornblihtt Alberto R   +2 more
exaly   +4 more sources

Alternative splicing in plants

Biochemical Society Transactions, 2008
The impact of AS (alternative splicing) is well-recognized in animal systems as a key regulator of gene expression and proteome complexity. In plants, AS is of growing importance as more genes are found to undergo AS, but relatively little is known about the factors regulating AS or the consequences of AS on mRNA levels and protein function.
Simpson, Craig G., Lewandowska, Dominika, Fuller, John, Maronova, Monika, Kalyna, Maria, Davidson, Diane, McNicol, Jim, Raczynska, Dorota, Jarmolowski, Artur, Barta, Andrea, Brown, John W. S.   +10 more
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Alternative splicing in ascomycetes

Applied Microbiology and Biotechnology, 2013
Alternative splicing is a complex and regulated process, which results in mRNA with different coding capacities from a single gene. Extend and types of alternative splicing vary greatly among eukaryotes. In this review, I focus on alternative splicing in ascomycetes, which in general have significant lower extend of alternative splicing than mammals ...
openaire   +2 more sources

Alternative Splicing in Disease

2007
Alternative splicing is a major source of diversity in the human proteome. The regulation of alternative splicingmodulates the composition of this diversity to fulfill the physiological requirements of a cell. When control of alternative splicing is disrupted, the result can be a failure to meet cellular and tissue requirements resulting in dysfunction
James P, Orengo, Thomas A, Cooper
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Alternative splicing and evolution

BioEssays, 2003
AbstractAlternative splicing is a critical post‐transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced ...
Stephanie, Boue, Ivica, Letunic, Peer, Bork   +2 more
openaire   +2 more sources

Function of alternative splicing

Gene, 2005
Alternative splicing is one of the most important mechanisms to generate a large number of mRNA and protein isoforms from the surprisingly low number of human genes. Unlike promoter activity, which primarily regulates the amount of transcripts, alternative splicing changes the structure of transcripts and their encoded proteins.
Stefan, Stamm, Shani, Ben-Ari, Ilona, Rafalska, Yesheng, Tang, Zhaiyi, Zhang, Debra, Toiber, T A, Thanaraj, Hermona, Soreq   +7 more
openaire   +2 more sources