Results 221 to 230 of about 197,929 (309)

Role of Alternative Splicing and Polyadenylation in Regulation of Spleen Development. [PDF]

Cells
Cui J, Zhu R, Song M, Sun Y, Pang Y, Tian M, He X, Liu D, Yang X.   +8 more
europepmc   +1 more source

Translational Gap in Biomarker Discovery: Tumor Surface Markers Rarely Mirror Circulating Levels

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Tumor‐associated cell surface proteins are frequently proposed as circulating biomarkers for colorectal cancer (CRC) based on their high tumor expression. However, many candidates identified through tissue‐based analyses fail to translate into clinically useful biomarkers.
Junko Mukohyama, Shohei F. Fujita, Xinyi Fu, Shigenori Suzuki, Hiroki Hamamoto, Dai Shida, Kimihiro Yamashita, Kohei Taniguchi, Sang‐Woong Lee, Akihide Yoshimi   +9 more
wiley   +1 more source

CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs. [PDF]

EMBO Mol Med
Wang W, Pan Z, Jing H, Shi R, Wu L, Wang J, Chen B, Mu J, Zhang Z, Wu T, Li Q, Shi J, Kuang Y, He L, Wang L, Sang Q.   +15 more
europepmc   +1 more source

Corrigendum: Modularized Perturbation of Alternative Splicing Across Human Cancers

Frontiers in Genetics, 2019
Yabing Du, Shoumiao Li, Ranran Du, Ni Shi, Seiji Arai, Seiji Arai, Sai Chen, Aijie Wang, Yu Zhang, Zhaoyuan Fang, Tengfei Zhang, Tengfei Zhang, Wang Ma, Wang Ma   +13 more
doaj   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Dysregulation of alternative splicing patterns in the ovaries of reproductively aged mice. [PDF]

Reproduction
Alsamaraee AT, Correll VL, Nyalwidhe JO, Brachova P, Alvarez NS, Alvarez NS.   +5 more
europepmc   +1 more source

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, EarlyView.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

Characterization of aberrant alternative splicing landscape in patients with metastatic renal cell carcinoma. [PDF]

J Immunother Cancer
Govindarajan A, Hansen N, Mercier BD, Byron SA, Hegde A, Garcia-Mansfield K, Leskoske K, Chawla N, Meza L, Zengin Z, Barragan-Carillo R, Ebrahimi H, Castro DV, Dizman N, Hsu J, Chehrazi-Raffle A, Tripathi A, Salgia NJ, Pal SK, Pirrotte P.   +19 more
europepmc   +1 more source

Therapeutic Outcomes in VEXAS Syndrome: A Multicenter Comparative Cohort of Allogeneic Hematopoietic Stem Cell Transplantation and Hypomethylating Agents

American Journal of Hematology, EarlyView.
ABSTRACT Hypomethylating agents (HMA) and allogeneic hematopoietic stem cell transplantation (alloHSCT) have both demonstrated remissions in VEXAS; however, comparative data is lacking. We conducted a multicenter, retrospective analysis of 66 patients diagnosed with VEXAS syndrome treated with HMA (n = 35) or alloHSCT (n = 31). Baseline characteristics
Saubia Fathima, Margaret Mei‐Kay Wong, Jesus Gonzalez‐Lugo, Susan M. Geyer, Ali Alsugair, Maria Sirenko, Kimberly J. Langer, Terra L. Lasho, Christy Finke, Jun Choi, Maher Abdul‐Hay, Gary Ho, Mark R. Litzow, Aasiya Matin, Urshila Durani, Mehrdad Hefazi, William J. Hogan, Mithun V. Shah, Aref Al‐Kali, Kebede H. Begna, Naseema Gangat, Antoine N. Saliba, Ronald S. Go, Tariq Kewan, Gabriel Bartoo, Jade Kutzke, Kristen McCullough, Kenneth J. Warrington, Megan Sullivan, Kaaren K. Reichard, Horatiu Olteanu, Hemant Murthy, Talha Badar, Yael Kusne, Jeanne Palmer, Saurabh Chhabra, Nathan Punwani, Mary Riwes, Joseph P. McGuirk, Elizabeth F. Krakow, Amelia Langston, Taxiarchis Kourelis, David Dingli, James Foran, Matthew J. Koster, Mrinal M. Patnaik, David B. Beck, Hassan B. Alkhateeb, Abhishek A. Mangaonkar   +48 more
wiley   +1 more source

Phosphate starvation induces root cell-type-specific transcriptional responses and alternative splicing. [PDF]

New Phytol
González-García MP, Lanza M, Baca-González V, Bustillo-Avendaño E, Serrano-Ron L, González-Bodi S, García-Mina JM, Zamarreño ÁM, Garnica M, Moreno-Risueno MA, Caro E, Del Pozo JC.   +11 more
europepmc   +1 more source