Results 221 to 230 of about 344,150 (327)

Characterization of Regulatory Mechanisms for Alternative Splicing in Alpha Thyroid Hormone Receptor mRNA

, 2010
Chao Zhang
openalex   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Species-specific alternative splicing of SP110 drives tuberculosis susceptibility in cattle. [PDF]

Vet Res
Fan A, Guo Y, Li Z, Dong X, Zhang Z, Wang X, Song Y, Han J, Yang J, Wang H, Zhang X, Zhang Y, Gao Y.   +12 more
europepmc   +1 more source

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

, 1992
Pier Paolo Pandolfi, Myriam Alcalay, M Fagioli, D Zangrilli, Amedea Mencarelli, Daniela Diverio, Andrea Biondi, Francesco Lo‐Coco, Alessandro Rambaldi, F Grignani   +9 more
openalex   +2 more sources

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review). [PDF]

Oncol Rep
Zhu W, Wu Z, Luv C, Bao B, Zhao W, Chen G, Yang H, Ai H, Liu F, Li Z.   +9 more
europepmc   +1 more source

The Role of mRNA Alternative Splicing in Macrophages Infected with Mycobacterium tuberculosis: A Field Needing to Be Discovered [PDF]

Weiling Hong, Hongxing Yang, Xiao Wang, Jingyi Shi, Jian Zhang, Jianping Xie   +5 more
openalex   +1 more source

Alternate Splicing [PDF]

, 2020
openaire   +1 more source

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing. [PDF]

FASEB J
Li J, Chen B, Wen Y, Wu Y, Liu K, Chen J, Wang S, Feng S, Dong J.   +8 more
europepmc   +1 more source