Results 221 to 230 of about 411,790 (378)

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Immunologically distinct p53 molecules generated by alternative splicing.

, 1986
Nobuyuki Arai, D Nomura, Kenji Yokota, D. Wolf, Eva Brill, O Shohat, Varda Rotter   +6 more
openalex   +1 more source

Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms. [PDF]

, 1993
Yuri A. Ushkaryov, Thomas C. Südhof
openalex   +1 more source

A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice

Advanced Science, EarlyView.
OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang, Yan Chun, Fan Zhang, Tingting Guo, Mengmeng Ren, Jinfeng Zhao, Shoujiang Yuan, Wensheng Wang, Yunhai Li, Xueyong Li   +9 more
wiley   +1 more source

MRAS: Master Regulator Analysis of Alternative Splicing. [PDF]

Adv Sci (Weinh)
Zhou L, Huang Y, Zhao Y, Guo D, Wen X, Xu R, Lv X, Wu S, Jing S, Liu Z.   +9 more
europepmc   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

Advanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu   +11 more
wiley   +1 more source

Analysis of the 5' end of the Drosophila muscle myosin heavy chain gene. Alternatively spliced transcripts initiate at a single site and intron locations are conserved compared to myosin genes of other organisms.

, 1987
D R Wassenberg, William A. Kronert, P T O'Donnell, Sanford I. Bernstein   +3 more
openalex   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Alternative branch points are selected during splicing of a yeast pre-mRNA in mammalian and yeast extracts.

, 1986
Barbara Ruskin, Claudio W. Pikielny, Michael Rosbash, M R Green   +3 more
openalex   +1 more source

Control of BEK and K-SAM Splice Sites in Alternative Splicing of the Fibroblast Growth Factor Receptor 2 Pre-mRNA [PDF]

, 1993
Emmanuelle Gilbert, Fabienne Del Gatto, Patrick Champion-Arnaud, Marie-Claude Gesnel, Richard Breathnach   +4 more
openalex   +1 more source