Results 261 to 270 of about 336,398 (336)

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Alternative splicing and residual function potentially expand the therapeutic landscape of the CFTRdele2ins182 variant. [PDF]

PLoS One
Pastorino C, Menta L, Pesce E, Lena M, Tomati V, Capurro V, Di Duca M, Terlizzi V, Gramegna A, Blasi F, Castellani C, Cappato S, Zara F, Pedemonte N, Bocciardi R.   +14 more
europepmc   +1 more source

Two Types of Non‐Abelian Topological Phase Transitions Under Duality Mapping in 1D Photonic Chains

Advanced Science, EarlyView.
In this work, two types of non‐Abelian phase transitions are revealed. The first type is the braided‐node type, signified by the Dirac degeneracy node moving into or out of the unit circle. The second type corresponds to the emerging of nodal‐line degeneracy which intersects with unit circles.
Yufu Liu, Yunlin Li, Jingguang Chen, Xianjun Wang, Haoran Zhang, Fang Guan, Xunya Jiang   +6 more
wiley   +1 more source

RPS27L Enhances Myogenesis and Muscle Mass by Targeting IGF1 Through Liquid‐Liquid Phase Separation

Advanced Science, EarlyView.
Muscle‐specific RPS27L knock‐in mice exhibit increased body weight, muscle mass, and enhanced muscle regenerative capacity. RPS27L drives myogenesis by promoting myoblast proliferation, while inhibiting myogenic differentiation. Mechanistically, RPS27L targets IGF1 protein by liquid‐liquid phase separation through its N‐terminal intrinsically ...
Xiaoqin Liu, Yilong Yao, Junyu Yan, Mu Zeng, Xinhao Fan, Yijie Tang, Jiju Li, Yanwen Liu, Shanying Yan, Wei Wang, Lijuan Chen, Ruipu Chen, Yuxin Huang, Honor Calnan, Heng Wang, Graham Gardner, Yalan Yang, Zhonglin Tang   +17 more
wiley   +1 more source

Leveraging 3D Molecular Spatial Visual Information and Multi‐Perspective Representations for Drug Discovery

Advanced Science, EarlyView.
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang, Xi Zhou, Yujie Qi, Xiaobo Zhu, Xun Deng, Feng Tan, Yuan Huang, Lun Hu, Zhuhong You, Pengwei Hu   +9 more
wiley   +1 more source

RNA G‐Quadruplex RIBOTAC‐Mediated Targeted Degradation of lncRNA TERRA

Advanced Science, EarlyView.
This study introduces a selective RNA degradation strategy targeting long noncoding RNA (lncRNA) TERRA, upregulated in ALT (alternative lengthening of telomeres) cancer cells. Using ribonuclease‐targeting chimeras (RIBOTACs), RNase L is recruited to catalytically degrade TERRA, uncovering a novel approach to affect a disease associated lncRNA in ALT ...
Elias Khaskia, Dipak Dahatonde, Raphael I. Benhamou   +2 more
wiley   +1 more source

The Role of Alternative Splicing in Marine-Freshwater Divergence in Threespine Stickleback. [PDF]

Genome Biol Evol
Rodríguez-Ramírez CE, Peichel CL.
europepmc   +1 more source

rMATS-cloud: Large-scale Alternative Splicing Analysis in the Cloud. [PDF]

Genomics Proteomics Bioinformatics
Adams JI, Kutschera E, Hu Q, Liu CJ, Liu Q, Kadash-Edmondson K, Liu S, Xing Y.   +7 more
europepmc   +1 more source

Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury

Advanced Science, EarlyView.
This study demonstrates that a hydrogel with mechanical properties matching the spinal cord directs fibroblast alignment, reshaping fibrotic scars into parallel matrices. A specific fibroblast subset mediates extracellular matrix remodeling through mechanotransduction, promoting axonal regeneration and neural reconnections, revealing potential ...
Longyou Xiao, Kaixi Shi, Wen Li, Jialin Liu, Pengfei Xie, Zijun Hu, Yu Dai, Haiyan Weng, Qiuju Yuan, Wutian Wu, Limin Rong, Liumin He   +11 more
wiley   +1 more source

Disrupted Alternative Splicing of RAB11FIP3 Contributes to Diabetic Foot Ulcer Dysfunction. [PDF]

J Cell Mol Med
Zhu D, Chen F, Li X, Ning Q, Wang J, Wei W, Zhang J, Shen C, Sun L, Gao J, Wang Z, Liu Y, Zhang A, Li Q, Jin P.   +14 more
europepmc   +1 more source