Results 261 to 270 of about 326,335 (355)

Bacterial Foreignization Nanosystem Elicits Multi‐Phenotypic T Cells for Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
In this study, a comprehensive strategy for tumor immunogenicity reshaping is implemented, in which all adjuvanticity, antigenicity, and reactogenicity of tumor cells are highly improved by an engineered bacterial nanosystem through a selective membrane fusion process. The resulting foreignized tumor cells evoke potent innate immune responses, inducing
Wan‐Ru Zhuang   +10 more
wiley   +1 more source

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

open access: yesAdvanced Science, EarlyView.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu   +13 more
wiley   +1 more source

Ezetimibe Engineered L14‐8 Suppresses Advanced Prostate Cancer by Activating PLK1/TP53‐SAT1‐Induced Ferroptosis

open access: yesAdvanced Science, EarlyView.
L14‐8, a small molecule derived from the marketed drug ezetimibe, potently inhibits advanced prostate cancer independent of androgen receptor signaling. L14‐8 binds PLK1, triggering its ubiquitin‐mediated degradation. This activates TP53‐dependent transcription of SAT1, inducing ferroptosis and suppressing tumor growth in prostate cancer patient ...
Yu Zhang   +8 more
wiley   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

open access: yesAdvanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen   +12 more
wiley   +1 more source

Current Progress and Challenges of Electromagnetic Wave Absorbing Materials at High Temperature

open access: yesAdvanced Science, EarlyView.
This review explains three dielectric loss mechanisms of electromagnetic wave absorbing materials under high temperatures and the high temperature testing technology is explained. The research progress of carbon‐based, ceramic‐based and metamaterial‐based electromagnetic wave absorbers is analyzed.
Zhixiao Wang   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy