Results 261 to 270 of about 344,150 (327)

Dual Subcellular Localization in the Endoplasmic Reticulum and Peroxisomes and a Vital Role in Protecting against Oxidative Stress of Fatty Aldehyde Dehydrogenase Are Achieved by Alternative Splicing

, 2007
Bunichiro Ashibe, Toshitake Hirai, Kyoichiro Higashi, Kazuhisa Sekimizu, Kiyoto Motojima   +4 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Quantifying annotation-driven bias in alternative splicing from EGAP metadata. [PDF]

NAR Genom Bioinform
de la Fuente R, Díaz-Villanueva W, Arnau V, Moya A.   +3 more
europepmc   +1 more source

Neuron-specific repression of alternative splicing by the conserved CELF protein UNC-75 in Caenorhabditis elegans [PDF]

Pallavi P. Pilaka-Akella, Nour H. Sadek, Daniel D. Fusca, Asher D. Cutter, John A. Calarco   +4 more
openalex   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source

MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer. [PDF]

Cancer Res
Pan T, Zhu J, Wang X, Tang D, Wang Z, Yang Y, Teng Y, Tian Q, Dan G, Chen C, Yu D, Liu M, Wang H, Zhang T, Guo B, Chen T, Jin B.   +16 more
europepmc   +1 more source

Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro

Advanced Science, EarlyView.
A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner, Petra B. Welzel, Maximilian Fusenig, Linda Sturm, Dagmar Pette, Wolfgang Wagermaier, Claudia Fischbach, Peter Fratzl, Carsten Werner   +8 more
wiley   +1 more source

Unveiling Alternative Splicing in HPV-Negative HNSCC: Links to Tumorigenesis and Immune Landscape. [PDF]

Int Dent J
Li S, Duan M, Ma X, Wu Y, Kang J, Tang Z, Tian X.   +6 more
europepmc   +1 more source

Gut Microbe‐Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

Advanced Science, EarlyView.
Acinetobacter regulates dinotefuran tolerance in Propylea japonica by mediating the expression of the horizontally transferred gene PjDUF1. Abstract Insect–microbial symbiont relationships are widespread in nature and often involve lateral gene transfer.
Ningbo HuangFu, Xiangzhen Zhu, Zhijuan Tang, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Jinjie Cui, Zhaojiang Guo, Junyu Luo, Xueke Gao   +10 more
wiley   +1 more source

Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity. [PDF]

Cell Death Dis
Duarte-Ruiz M, Moreno-Castillo A, El Yousfi Y, Moreno-Castro C, Martínez-Martínez N, Jiménez-Lozano S, Kennel M, Ruiz-Rodríguez C, Rodríguez-Caparrós A, López-Ros J, de la Grange P, Hernández-Munain C, Suñé C.   +12 more
europepmc   +1 more source