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Alternative splicing and evolution
BioEssays, 2003AbstractAlternative splicing is a critical post‐transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced ...
Stephanie, Boue +2 more
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Function of alternative splicing
Gene, 2005Alternative splicing is one of the most important mechanisms to generate a large number of mRNA and protein isoforms from the surprisingly low number of human genes. Unlike promoter activity, which primarily regulates the amount of transcripts, alternative splicing changes the structure of transcripts and their encoded proteins.
Stefan, Stamm +7 more
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Predicting Alternative Splicing
2014Alternative splicing of pre-mRNA is a complex process whose outcome depends on elements reviewed in the previous chapters such as the core spliceosome units, how the core spliceosome units interact between themselves and with other splicing enhancers and repressors, primary sequence motifs, and local RNA secondary structure.
Yoseph, Barash, Jorge Vaquero, Garcia
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Alternative splicing in the testes
Current Opinion in Genetics & Development, 2002Germ-cell differentiation is an ideal process for studying the effects of alternative splicing and there are examples of alternative splicing of genes involved in gene regulation and signal transduction at every stage of the spermatogenic pathway. A network of testes-specific splicing factor interactions has been uncovered and combining our knowledge ...
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Alternative transcription and alternative splicing in cancer
Pharmacology & Therapeutics, 2012In recent years, the notion of "one gene makes one protein that functions in one signaling pathway" in mammalian cells has been shown to be overly simplistic. Recent genome-wide studies suggest that at least half of the human genes, including many therapeutic target genes, produce multiple protein isoforms through alternative splicing and alternative ...
Sharmistha, Pal +2 more
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Alternative Splicing of Amelogenins
Connective Tissue Research, 1995Amelogenins comprise as much as 90% of the protein in the developing enamel matrix. Separating amelogenins by gel electrophoresis reveals a complex of polypeptides with apparent mobilities ranging from low molecular weight species on up to 28,000 Daltons.
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Alternative splicing in Alzheimer’s disease
Aging Clinical and Experimental Research, 2019Alzheimer's disease (AD) is the most frequent neurodegenerative disorder in the elderly, occurring in approximately 20% of people older than 80. The molecular causes of AD are still poorly understood. However, recent studies have shown that Alternative Splicing (AS) is involved in the gene expression reprogramming associated with the functional changes
Biamonti G +6 more
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Regulation of Alternative Splicing
1990With careful study of the array of RNAs produced by many different genes, it has become clear that alternative splicing is an important mechanism for the regulation of the synthesis of various biologically important proteins. The simplest form of such regulation results from the tissue- or temporal-specific splicing events that lead alternatively to ...
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Editorial – splicing and alternative splicing
The International Journal of Biochemistry & Cell Biology, 2019Jose-Luis, Capelo-Martinez +3 more
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