Results 261 to 270 of about 197,929 (309)

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, EarlyView.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

Functional rescue of a disease-linked ERAD pathway mutation via alternative splicing. [PDF]

EMBO J
Wang HH, Wang Z, Lin LL, Verma SK, Gniadzik W, Wang H, Li ZJ, Whitestone E, Jiang L, Kuyumcu-Martinez MN, Sun S, Qi L.   +11 more
europepmc   +1 more source

Genetic‐Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to identify plasma proteins driving MS susceptibility using large‐scale proteogenomic integration and to evaluate their prediagnostic ...
Yuan Ding, Dylan Hamitouche, Simon Thebault, Patrick Kearns, Ahmed Abdelhak, Adil Harroud   +5 more
wiley   +1 more source

hnRNPM cooperates with BCAS2 to modulate alternative splicing during oocyte development. [PDF]

Nat Commun
Zhou S, Liu D, Gan S, Yu Z, Su R, Zhou H, Zhang J, Xu H, Zhao Y, Zhang H, Deng Z, Wu X, Luo C, Liu Y, Yuan S, Fan HY, Sun F.   +16 more
europepmc   +1 more source

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

Annals of Neurology, EarlyView.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto, Michael Bonomo, Brianna S. Nelthrope, Benjamin D. Carr, Emma Palmer, Mariana Sierra, Ilkim Erturk, David Peppercorn, Eleonor Cox, Tiare K. Vasconcellos, Henry L. Paulson, Hannah K. Shorrock, Sharan R. Srinivasan   +12 more
wiley   +1 more source

Dynamic Landscape of Alternative Splicing During Early Embryogenesis of the Rhesus Monkey. [PDF]

Int J Mol Sci
Li A, Zhang Y, Zhai Y, Xing Y.
europepmc   +1 more source

Dataset reporting the differential effect of <i>HNRNPA1</i> isoforms on alternative splicing. [PDF]

Data Brief
Deshaies JE, Triassi V, Tétreault M, Vande Velde C.   +3 more
europepmc   +1 more source

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Alternative splicing in plants

Biochemical Society Transactions, 2008
The impact of AS (alternative splicing) is well-recognized in animal systems as a key regulator of gene expression and proteome complexity. In plants, AS is of growing importance as more genes are found to undergo AS, but relatively little is known about the factors regulating AS or the consequences of AS on mRNA levels and protein function.
Simpson, Craig G., Lewandowska, Dominika, Fuller, John, Maronova, Monika, Kalyna, Maria, Davidson, Diane, McNicol, Jim, Raczynska, Dorota, Jarmolowski, Artur, Barta, Andrea, Brown, John W. S.   +10 more
openaire   +3 more sources

Alternative splicing in ascomycetes

Applied Microbiology and Biotechnology, 2013
Alternative splicing is a complex and regulated process, which results in mRNA with different coding capacities from a single gene. Extend and types of alternative splicing vary greatly among eukaryotes. In this review, I focus on alternative splicing in ascomycetes, which in general have significant lower extend of alternative splicing than mammals ...
openaire   +2 more sources

Alternative Splicing in Disease

2007
Alternative splicing is a major source of diversity in the human proteome. The regulation of alternative splicingmodulates the composition of this diversity to fulfill the physiological requirements of a cell. When control of alternative splicing is disrupted, the result can be a failure to meet cellular and tissue requirements resulting in dysfunction
James P, Orengo, Thomas A, Cooper
openaire   +2 more sources