Results 161 to 170 of about 877,869 (275)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Alternative Therapies for Non-Motor Symptoms in Parkinson's Disease: A Mini Review. [PDF]

Neuropsychiatr Dis Treat
Liu H, Wang XP.
europepmc   +1 more source

Bibliometric trend analysis of non-conventional (alternative) therapies in veterinary research. [PDF]

Vet Q, 2022
Domingues K, Franco NH, Rodrigues I, Stilwell G, Magalhães-Sant'Ana M.   +4 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Beyond Antivirals: Alternative Therapies for Long COVID. [PDF]

Viruses
Livieratos A, Gogos C, Akinosoglou K.
europepmc   +1 more source

Complementary and alternative therapies in skin cancer a literature review of biologically active compounds. [PDF]

Dermatol Ther, 2022
Hidalgo L, Saldías-Fuentes C, Carrasco K, Halpern AC, Mao JJ, Navarrete-Dechent C.   +5 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative Therapies. [PDF]

Microorganisms
Hu M, Chua SL.
europepmc   +1 more source

Alternative therapies for dry eye disease. [PDF]

Curr Opin Ophthalmol, 2021
Mittal R, Patel S, Galor A.
europepmc   +1 more source

Complementary and Alternative Medicine (CAM) Therapies in the Treatment of Meniere's Syndrome: Illness Narratives [PDF]

, 2008
Bennett, T, Brettle, A, Long, AF, Xing, M   +3 more
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