Results 251 to 260 of about 261,784 (335)

Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing

, 2019
James Chan
openalex   +2 more sources

Revisiting the approaches to DNA damage detection in genetic toxicology: insights and regulatory implications. [PDF]

BioData Min
Alnasser SM.
europepmc   +1 more source

In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock, Jihyun Park, Dae‐Gyu Jang, Bangyao Zhao, Samuel J. Teener, Ian F. Webber‐Davis, Lili Zhao, Eva L. Feldman, Stephen A. Goutman   +8 more
wiley   +1 more source

Alternative Methods Replacing Animal Testing in Research: An Overview

, 2019
Abhishek Singh, Preeti Singh
openalex   +1 more source

New advanced models (NAMs) for risk assessment of bisphenol A alternatives. [PDF]

EFSA J
Honza T, El Yamani N, Dusinska M, Rundén-Pran E, Marcon F.   +4 more
europepmc   +1 more source

Remaining Burden of Spinal Muscular Atrophy Among Treated Patients: A Survey of Patients and Caregivers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal muscular atrophy (SMA) significantly impacts motor function. This study aimed to assess the persistent burden and unmet needs among currently treated patients with SMA and their caregivers. Methods Two complementary web‐based surveys were distributed in August 2024 among patients with SMA and their caregivers.
Julie A. Parsons, Natalie Land, Melissa Culhane Maravic, Claire Cagle, Amal Jamaleddine, Hemal Shah, Thomas Brown, Christabella Cherubino, Mouhamed Gueye   +8 more
wiley   +1 more source

Organophosphorus Flame Retardant, Phthalate, and Alternative Plasticizer Contamination in Novel Plant-Based Food: A Food Safety Investigation. [PDF]

Environ Sci Technol
Macan Schönleben A, den Ouden F, Yin S, Fransen E, Bosschaerts S, Andjelkovic M, Rehman N, van Nuijs ALN, Covaci A, Poma G.   +9 more
europepmc   +1 more source

Letter to: Real‐World Clinical Experience With Serum MOG and AQP4 Antibody Testing by Live Versus Fixed Cell‐Based Assay

Annals of Clinical and Translational Neurology, EarlyView.
Adrian Budhram
wiley   +1 more source

Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont, Adam Deardorff, Murad Nawaz, Andrew A. Voss, Mark M. Rich   +4 more
wiley   +1 more source

The effects of handling on mouse behavior: cupped hands versus familiar or novel huts or tunnels. [PDF]

PLoS One
Bodnar MJ, Makowska IJ, Schuppli CA, Weary DM.   +3 more
europepmc   +1 more source