Results 81 to 90 of about 350,286 (305)

Hypoxic preacclimatization combining intermittent hypoxia exposure with physical exercise significantly promotes the tolerance to acute hypoxia

Frontiers in Physiology
Background: Both hypoxia exposure and physical exercise before ascending have been proved to promote high altitude acclimatization, whether the combination of these two methods can bring about a better effect remains uncertain.
Jiaxin Xie, Shenwei Xie, Zhifeng Zhong, Huaping Dong, Pei Huang, Simin Zhou, Huaijun Tian, Jijian Zhang, Yu Wu, Peng Li   +9 more
doaj   +1 more source

Hypoxia Exacerbates Inflammatory Acute Lung Injury via the Toll-Like Receptor 4 Signaling Pathway

Frontiers in Immunology, 2018
Acute lung injury (ALI) is characterized by non-cardiogenic diffuse alveolar damage and often leads to a lethal consequence, particularly when hypoxia coexists.
Gang Wu, Gang Wu, Gang Xu, Gang Xu, De-Wei Chen, De-Wei Chen, Wen-Xiang Gao, Wen-Xiang Gao, Jian-Qiong Xiong, Hai-Ying Shen, Yu-Qi Gao, Yu-Qi Gao   +11 more
doaj   +1 more source

Capillary supply and fiber morphometry in rat myocardium after intermittent exposure to hypobaric hypoxia. [PDF]

, 2013
Panisello, Pere, Joan Ramon Torrella, Teresa Pagés, and Ginés Viscor. Capillary supply and fiber morphometry in rat myocardium after intermittent exposure to hypobaric hypoxia. High Alt. Med. Biol. 8:322-330, 2007.
Panisello Tafalla, Pere, Torrella Guio, Joan Ramon, Pagés, Teresa, Viscor Carrasco, Ginés   +3 more
core   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Integration of the D‐Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability

Advanced Science, EarlyView.
Integration of the D‐genome reshapes gene transcription, chromatin architecture, and the metabolome of hexaploid wheat, leading to enhanced adaptability to salt, UV‐B, and alkali stress. ABSTRACT The hybridization‐led integration of the D‐genome into domesticated tetraploid wheat gave rise to allohexaploid wheat, the most cultivated wheat globally ...
Yanyan Liu, Tao Zhu, Ziru Zhou, Wei Chen, Chao He, Xinkai Zhou, Xin Wang, Chuanye Chen, Bo Yang, Jiaqi Wei, Caixia Lan, Mengmeng Liu, Handong Su, Qiang Li, Xin Hu, Siteng Bi, Weizhi Ouyang, Xingwang Li, Hailiang Mao, Masahiro Kishi, Kerstin Kaufmann, Alisdair R. Fernie, Dijun Chen, Wenhao Yan   +23 more
wiley   +1 more source

Adriamycin-induced podocyte injury via the Sema3A/TRPC5/Rac1 pathway

Frontiers in Medicine
Podocytopathies encompass kidney diseases where direct or indirect podocyte injury leads to proteinuria or nephrotic syndrome. Although Semaphorin3A (Sema3A) is expressed in podocytes and tubular cells in adult mammalian kidneys and has a common effect ...
Yan Liu, Yan Liu, Ri-Li Ge, Zhen-Zhen Shan, Yan-Jun Wang, Yan-Yan Yang, Xue Sun, Peng-Li Luo, Peng-Li Luo   +8 more
doaj   +1 more source

Effect of inhaled nitric oxide on oxygen-carrying capacity of red blood cells and hypoxia tolerance in mice

Di-san junyi daxue xuebao, 2019
Objective To study the effects of nitric oxide (NO) inhalation on oxygen-carrying capacity of red blood cells and hypoxia tolerance in mice. Methods Peripheral blood from 8-week-old male mice was exposed to nitrogen gas containing NO in an oxygenation ...
SU Wenting, CUI Yu, LI Xiaoxu, GUAN Libin   +3 more
doaj   +1 more source

High‐Brightness and Ultra‐Long‐Lifetime Spin Quantum Dot Light‐Emitting Diodes Enabled by Efficient Injection of Spin‐Polarized Holes Through a Hybrid Hole Transport Layer

Advanced Science, EarlyView.
This work employs a hybrid hole transport layer to enhance hole transport efficiency, resulting in improved performance for the final device. It achieves an external quantum efficiency of 6.68%, a circularly polarized electroluminescence asymmetry factor of 0.026, and a high luminance of 14,370 cd/cm2, representing the highest luminance reported to ...
Fengqi Qiu, Hechun Zhang, Wenbo Liu, Guiming Zhong, Fumin Lu, Yuqi Wang, Fujin Ai, Kai Wang, Dan Wu   +8 more
wiley   +1 more source

Tumor cell-derived EMP1 is essential for cancer-associated fibroblast infiltration in tumor microenvironment of triple-negative breast cancer

Cell Death and Disease
The role of epithelial membrane protein 1 (EMP1) in tumor microenvironment (TME) remodeling has not yet been elucidated. In addition, the biological function of EMP1 in triple-negative breast cancer (TNBC) is largely unclear.
Qi Wang, Dandan Li, Haixiu Ma, Zengyan Li, Juan Wu, Jinwan Qiao, Jun Liu, Jing Zhao, Ronghua Ma, Lin Tian, Lei Zhang, Jianye Yang, Jianing Wang, Shanshan Qin, Zhanhai Su   +14 more
doaj   +1 more source

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source