Results 71 to 80 of about 350,286 (305)

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Waves and Magnetism in the Solar Atmosphere (WAMIS)

Frontiers in Astronomy and Space Sciences, 2016
Comprehensive measurements of magnetic fields in the solar corona have a long history as an important scientific goal. Besides being crucial to understanding coronal structures and the Sun’s generation of space weather, direct measurements of their ...
Yuan-Kuen eKo, John Daniel Moses, John Martin Laming, Leonard eStrachan, Samuel eTun Beltran, Steven eTomczyk, Sarah E. Gibson, Frederic eAuchere, Roberto eCasini, Silvano eFineschi, Michael eKnoelker, Clarence eKorendyke, Scott William McIntosh, Marco eRomoli, Jan eRybak, Dennis G. Socker, Angelos eVourlidas, Qian eWu   +17 more
doaj   +1 more source

Exercise-Induced Hypoxaemia Developed at Sea-Level Influences Responses to Exercise at Moderate Altitude [PDF]

, 2016
The aim of this study was to investigate the impact of exercise-induced hypoxaemia (EIH) developed at sea-level on exercise responses at moderate acute altitude.
Subirats Bayego, Enric, Durand, Fabienne, Doucende, Grégory, Grégory Doucende (3094596), Hapkova, Ilona, Fabienne Durand (3094593), Ilona Hapkova (3094581), Enric Subirats, Anne-Fleur Gaston (3094590), Emma Roca (3094587), Emma Roca, Gaston, Anne-Fleur, Roca, Emma, Anne-Fleur Gaston, Fabienne Durand, Ilona Hapkova, Grégory Doucende, Enric Subirats (3094584), Subirats, Enric   +18 more
core   +1 more source

Low Latency Global Carbon Budget Reveals Late 2024 Carbon Losses and Contrasting Early 2025 Land Sink Recovery Signals

Advanced Science, EarlyView.
Low latency carbon budget estimates for July 2024–June 2025 combine atmospheric CO2 growth rates, fossil emissions, ocean uptake, DGVM land fluxes, and OCO‐2 inversions. The budget shows that late‐2024 land carbon losses dominate the annual anomaly, while early‐2025 recovery differs between bottom‐up models and top‐down inversions, especially in ...
Piyu Ke, Philippe Ciais, Yitong Yao, Stephen Sitch, Wei Li, Xiaomeng Du, Xiaofan Gui, Ben Poulter, Thomas Colligan, Auke M. van der Woude, Joram Hooghiem, Wouter Peters, Zhu Liu, Zhu Deng, Zhe Jin, Xiangjun Tian, Yilong Wang, Junjie Liu, Sudhanshu Pandey, Chris O'Dell, Jiang Bian, John Miller, Xin Lan, Jefferson Goncalves De Souza, Michael O'Sullivan, Pierre Friedlingstein, Julien Alléon, Yi Xi, Daniel S. Goll, Lei Zhu, Guido R. van der Werf, Shilong Piao, Frédéric Chevallier   +32 more
wiley   +1 more source

Bridging Horizontal to Vertical Radiative Cooling

Advanced Science, EarlyView.
Radiative cooling materials are mature but only work facing the sky, confining them to rooftops. Instead of developing new ones, this system bridges existing horizontal coolers to vertical windows using blades outside the glass. On an occupied urban building, windows stay up to 1.4°C below air temperature while preserving daylight, outward views, and ...
Xiangyu Meng, Gan Huang
wiley   +1 more source

UHPLC-QTOFMS-Based Metabolomic Analysis of the Hippocampus in Hypoxia Preconditioned Mouse

Frontiers in Physiology, 2019
Background: Hypoxia appears in a number of extreme environments, including high altitudes, the deep sea, and during aviation, and occurs in cancer, cardiovascular disease, respiratory failures and neurological disorders. Though it is well recognized that
Wen-Ting Liao, Jie Liu, Jie Liu, Si-Min Zhou, Si-Min Zhou, Gang Xu, Gang Xu, Yu-Qi Gao, Yu-Qi Gao, Wen-Yuan Liu   +9 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Altitude hypoxia and hypoxemia: pathogenesis and management

Signal Transduction and Targeted Therapy
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availability and a ...
Chunmei Cai, Guohua Ni, Lei Chen, Cheng Deng, Shengjun Chai, Rui Wang, Rong Zhang, Fengming Luo, Ri-Li Ge   +8 more
doaj   +1 more source

Adaptation to Living at High Altitude in Patients with COPD. Comparative Study of Exercise Capacity and Ventilatory Variables between Patients Residing at High and Low Altitudes in the Andes

González-García, Mauricio and Luis Ernesto Téllez. Adaptation to living at high altitude in patients with COPD. Comparative study of exercise capacity and ventilatory variables between patients residing at high and low altitudes in the Andes.
Téllez L.E., González-García M.
core   +1 more source

Polydopamine‐Wool Textiles for Sustainable Interfacial Solar Vapor Generation

Advanced Science, EarlyView.
A natural wool textile engineered for high solar absorbance and a fast‐wicking structure serves as a highly efficient, single‐layer system for interfacial solar vapor generation (ISVG). This integrated evaporator seamlessly couples rapid water transport with continuous evaporation. Ultimately, this sustainable photothermal design offers a scalable, eco‐
Kyuin Park, Jintong Gao, Hansadi Jayamaha, Yipu Wang, Mia Bressler, Lenan Zhang, Larissa M. Shepherd   +6 more
wiley   +1 more source