Results 41 to 50 of about 32,385 (167)

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Model predictive control with inline parameter adaptation for direct crystal growth rate regulation

AIChE Journal, EarlyView.
Abstract In batch cooling crystallization, many interactive factors, including supersaturation, reactor dimensions, and operating conditions, govern crystal growth and significantly influence product properties. Variables such as temperature or refractive index are used as surrogate control variables but have limitations in capturing growth rate ...
Huitian Yu, Jiewen Zhao, Heiko Briesen
wiley   +1 more source

CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda, Toshihiko Komai, Takahiro Itamiya, Tatsuki Abe, Tomohisa Okamura, Keishi Fujio   +5 more
wiley   +1 more source

Temporal Inquiry Horizons: Valuing New Scholarship

Canadian Journal for New Scholars in Education, 2012
In this article, I consider new scholarship and new scholars in education within the construct of the metaphor of new inquiry horizons. In this way, I highlight the great value of new scholarship and underscore the significance of this journal for ...
Candace Schlein
doaj  

Harnessing Native Al/Si Impurities in Bamboo Black Liquor for Self‐Templated Closed‐Pore Hard Carbon Anodes

Carbon Energy, EarlyView.
A scalable strategy utilizing native impurities in bamboo lignin black liquor is proposed to construct a closed‐pore, rich hard carbon. Controlled impurity removal and high‐temperature reconstruction enable the conversion of open pores into abundant closed pores, thereby promoting sodium cluster storage.
Zhenbing Sun, Qi Yu, Yujun Li, Lin Zhao, Zhenrui Li, Haifeng Zuo, Qinxuan Shi, Zehui Jiang, Qianli Ma, Xing'e Liu   +9 more
wiley   +1 more source

Comprehensive Physicochemical Characterization and Wound Healing Efficacy of Alum and Its Processed Products: Insights from XRD, Raman, TGA and Low-Field NMR Analyses in a Mouse Model

Natural Product Communications
Objective: This study aims to compare the relevant characteristics of alum and its processed products and investigate their effects on skin wound healing using x-ray diffraction (XRD), Raman spectroscopy, thermogravimetric analysis (TGA), and low-field ...
Xinxin Yang, Shuang Kang, Jing Liu, Jiaojiao Ran, Zijun Huang, Chuying Wang, Peng Yu   +6 more
doaj   +1 more source

Critical Thinking Emulation Model With Outcomes‐Based Assessment

Journal of Dental Education, EarlyView.
ABSTRACT Background/Purpose Gaps exist between critical thinking importance and an organized agenda for the development of critical thinking learning outcomes. Multiple critical thinking skill sets were developed by the authors, forming a symbiotic network.
David C Johnsen, Leonardo Marchini, Carlos Garaicoa‐Pazmino, Aditi Jain, John Syrbu, Matthew Geneser, Azeez Butali, Jennifer E Hartshorn, Jhanvi Desai, Clark M Stanford, Kim Vo, Michael Spector, Nicole McGlynn, L Brendan Young   +13 more
wiley   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Exploring the Role of Special Events in Relationship Fundraising

Nonprofit Management and Leadership, EarlyView.
ABSTRACT The relationship fundraising paradigm conceptualizes charitable giving as an outcome of ongoing interpersonal engagement between donors and organizations, often depicted in practice as a cyclical process with multiple phases. This study examines how special events—a widely used but understudied relationship fundraising tool—factor into this ...
Jason L. Jensen, Benjamin J. Kassow, Genevieve G. Shaker, Paul E. Sum   +3 more
wiley   +1 more source