Results 21 to 30 of about 2,097,845 (216)

Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair

Signal Transduction and Targeted Therapy, 2022
Maxillofacial bone defects are commonly seen in clinical practice. A clearer understanding of the regulatory network directing maxillofacial bone formation will promote the development of novel therapeutic approaches for bone regeneration. The fibroblast
Yi Fan, C. Cui, C. Rosen, Tadatoshi Sato, R. Xu, Peiran Li, Xi Wei, R. Bi, Q. Yuan, Chenchen Zhou   +9 more
semanticscholar   +1 more source

LPS-Induced Premature Osteocyte Senescence: Implications in Inflammatory Alveolar Bone Loss and Periodontal Disease Pathogenesis

Bone, 2020
Cellular senescence is associated with inflammation and extracellular matrix tissue remodeling through the secretion of proteins termed the senescence-associated secretory phenotype (SASP).
R. Aquino-Martinez, Jennifer L. Rowsey, Daniel G. Fraser, Brittany A. Eckhardt, S. Khosla, J. Farr, D. Monroe   +6 more
semanticscholar   +1 more source

Nanotechnology Scaffolds for Alveolar Bone Regeneration

Materials, 2020
In oral biology, tissue engineering aims at regenerating functional tissues through a series of key events that occur during alveolar/periodontal tissue formation and growth, by means of scaffolds that deliver signaling molecules and cells.
G. Funda, S. Taschieri, G. Bruno, E. Grecchi, Savadori Paolo, Donati Girolamo, M. Del Fabbro   +6 more
semanticscholar   +1 more source

The roles of osteocytes in alveolar bone destruction in periodontitis

Journal of Translational Medicine, 2020
Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar bone loss in periodontitis is crucial for understanding its pathogenesis.
Xiaofei Huang, Mengru Xie, Yanling Xie, Feng Mei, Xiaofeng Lu, Xiaoshuang Li, Lili Chen   +6 more
semanticscholar   +1 more source

Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress

Theranostics, 2020
Periodontitis is a widespread oral disease that results in the loss of alveolar bone. Low-intensity pulsed ultrasound (LIPUS), which is a new therapeutic option, promotes alveolar bone regeneration in periodontal bone injury models.
Siqi Ying, Minmin Tan, G. Feng, Yunchun Kuang, Duanjing Chen, Jie Li, Jinlin Song   +6 more
semanticscholar   +1 more source

A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: Antibacterial, hemostasis, immune reprogramming, pro-osteo-/angiogenesis and recruitment

Bioactive Materials
Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues, resulting in tooth loss. Poor eradication of pathogenic microorganisms, persistent malignant inflammation and impaired osteo-/angiogenesis are ...
Shiyuan Yang, Yan Zhu, Chunxiao Ji, Huimin Zhu, An Lao, Ran Zhao, Yue Hu, Yu-ning Zhou, Jia Zhou, Kaili Lin, Yuanjin Xu   +10 more
semanticscholar   +1 more source

Probiotics ameliorate alveolar bone loss by regulating gut microbiota

Cell Proliferation, 2020
Oestrogen deficiency is an aetiological factor of postmenopausal osteoporosis (PMO), which not only decreases bone density in vertebrae and long bone but also aggravates inflammatory alveolar bone loss.
L. Jia, Ye Tu, Xiaoyue Jia, Qian Du, Xin Zheng, Quan Yuan, Liwei Zheng, Xuedong Zhou, Xin Xu   +8 more
semanticscholar   +1 more source

Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway

Journal of Nanobiotechnology
Impaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in the pathogenesis of the alveolar bone defect caused by periodontitis.
Shiyuan Yang, Yue Hu, Ran Zhao, Yuning Zhou, Zhuang Yu, Yan Zhu, Xiao-Li Ge, Tingting Lu, Kaili Lin, Yuanjin Xu   +9 more
semanticscholar   +1 more source

The dimension and morphology of alveolar bone at maxillary anterior teeth in periodontitis: a retrospective analysis—using CBCT

International Journal of Oral Science, 2020
The morphology of the alveolar bone at the maxillary anterior teeth in periodontitis patients was evaluated by cone-beam computed tomography (CBCT) to investigate the distribution of alveolar defects and provide guidance for clinical practice.
Xue Zhang, Yuchao Li, Ziming Ge, Haijiao Zhao, Lei Miao, Yaping Pan   +5 more
semanticscholar   +1 more source

Icariin prevents oestrogen deficiency–induced alveolar bone loss through promoting osteogenesis via STAT3

Cell Proliferation, 2020
Alveolar bone osteoporosis has attracted more and more attention because of its profound impact on stomatognathic function and treatment, but current treatments have not been targeted to alveolar bone and might even cause severe side effects.
Hongyuan Xu, Siru Zhou, R. Qu, Yiling Yang, X. Gong, Yueyang Hong, A. Jin, Xiangru Huang, Q. Dai, Lingyong Jiang   +9 more
semanticscholar   +1 more source