Results 181 to 190 of about 1,231,896 (240)

Mertk drives alveolar bone loss in experimental periodontitis associated with altered neutrophil function and osteoclast recruitment

open access: yesJournal of Periodontology, EarlyView.
Abstract Background Alveolar bone loss is the hallmark of periodontitis and often remains refractory to conventional mechanical and antimicrobial therapies in chronic cases. Mer receptor tyrosine kinase (Mertk) has been implicated in bone homeostasis, yet the immune mechanisms by which Mertk modulates periodontal bone resorption remain insufficiently ...
Nicholas Mazzara   +8 more
wiley   +1 more source

Dental enamel hypoplasia and intra‐tooth isotope records as indicators of physiological stress and environmental variability in Early Pleistocene hippopotamids from Melka Kunture (Upper Awash, Ethiopia)

open access: yesJournal of Quaternary Science, EarlyView.
ABSTRACT Enamel hypoplasia results from temporary disruptions of enamel deposition during tooth development. It is widely used as an indicator of physiological stress in archeological and paleontological contexts; yet, its relationship with environmental conditions during tooth formation remains poorly constrained.
Giuseppe Briatico   +3 more
wiley   +1 more source

Outcomes of Osseous Microvascular Midface Reconstruction: Does Union Matter?

open access: yesThe Laryngoscope, EarlyView.
ABSTRACT Objective(s) To assess rates of bony union and their correlation with postoperative complications following osseous orbitomaxillary microvascular reconstruction. Methods A retrospective review was performed of patients who underwent orbitozygomaticomaxillary reconstruction with composite osseous free flaps at an academic medical center from ...
Edgar Ochoa   +6 more
wiley   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

open access: yesMed Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu   +9 more
wiley   +1 more source

Mapping Tumor Recurrence and Metastasis With Pan‐Cancer Multi‐Omics

open access: yesMed Research, EarlyView.
Tumor recurrence and metastasis arise from the interaction of shared evolutionary programs and context‐dependent modifiers. Clonal evolution, including genomic instability, subclonal selection, and treatment pressure, interacts with reversible cell‐state plasticity involving partial EMT, stemness, and dormancy, whereas immune escape, stromal remodeling,
Wenjun Meng   +13 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli   +5 more
wiley   +1 more source

Targeted Muscle Reinnervation for Intuitive Prosthetic Control

open access: yesMuscle &Nerve, EarlyView.
ABSTRACT The convergence of medical and technological advances has led to a substantial expansion of therapeutic approaches for patients with limb amputations. Targeted muscle reinnervation (TMR) is one of the strategies to improve control of bionic arms and has been applied for more than two decades. Through surgical rewiring of the nerves responsible
Nitay Maile   +5 more
wiley   +1 more source

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