Results 131 to 140 of about 9,230,509 (381)

The Case of a 67‐Year‐Old Man With Memory Difficulties and Altered Sleep

Annals of Clinical and Translational Neurology, EarlyView.
Wesley Peng, Borna Bonakdarpour
wiley   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

The African American Dementia and Aging Project: an Oregon-based longitudinal study

Frontiers in Dementia
IntroductionThe vast majority of studies on aging, cognition, and dementia focus on non-Hispanic white subjects. This paper adds to the extant literature by providing insight into the African American aging experience.
Allison Lindauer, Allison Lindauer, Raina Croff, Raina Croff, Kevin Duff, Kevin Duff, Nora Mattek, Nora Mattek, Patrice Fuller, Patrice Fuller, Aimee Pierce, Aimee Pierce, Kalisha Bonds Johnson, Jeffrey Kaye, Jeffrey Kaye   +14 more
doaj   +1 more source

Cell Loss from the Nucleus Basalis of Meynert in Alzheimer's Disease [PDF]

, 1986
R. Doucette, Michael Fisman, V C Hachinski, H. Mersky   +3 more
openalex   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Predicting time to dementia using a quantitative template of disease progression

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Characterization of longitudinal trajectories of biomarkers implicated in sporadic Alzheimer's disease (AD) in decades before clinical diagnosis is important for disease prevention and monitoring.
Murat Bilgel, Bruno M. Jedynak, Alzheimer's Disease Neuroimaging Initiative   +2 more
doaj   +1 more source

Neurological Abnormalities Associated with Severity of Dementia in Alzheimer's Disease [PDF]

, 1986
F. Jacob Huff, John H. Growdon
openalex   +1 more source

Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup

Alzheimer's & Dementia
The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD).
Clifford R Jack, J. S. Andrews, Thomas G. Beach, Teresa Buracchio, B. Dunn, Ana Graf, Oskar Hansson, Carole Ho, William Jagust, E. McDade, J. Molinuevo, O. Okonkwo, Luca Pani, M. Rafii, P. Scheltens, Eric R. Siemers, H. Snyder, R. Sperling, C. Teunissen, Maria C. Carrillo   +19 more
semanticscholar   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Alzheimer's Disease [PDF]

Neurobiology of Disease, 2000
openaire   +5 more sources