Results 111 to 120 of about 340,510 (279)

Promotores program to increase Hispanic/Latino(a) participation in Alzheimer's disease research

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Hispanic/Latino(a/x) (H/L) representation in Alzheimer's disease and related dementias (ADRD) research remains low, limiting generalizability of findings and interventions to this growing population. H/L community health workers (“Promotores”
Zvinka Z. Zlatar, Christina Gigliotti, Ivonne Arias, Rosa Gutierrez Aceves, Mariana Perez, Emily A. Little, Carol Evans, Jose A. Soria, Branko N. Huisa, Diane M. Jacobs, Douglas Galasko, David P. Salmon, Guerry M. Peavy   +12 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Fiscal Year 2012

, 2012
Annual financial report of the Texas Council on Alzheimer's Disease and Related Disorders documenting income, expenditures, and other relevant financial information for fiscal year ...
Texas Council on Alzheimer's Disease & Related Disorders
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Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease

BackgroundGenome-wide association studies (GWAS) have identified numerous genetic variants associated with Alzheimer's disease (AD), but their functional implications remain unclear.
Bush, William S, Naj, Adam C, Below, Jennifer E, Griswold, Anthony J, Alzheimer's Disease Genetics Consortium, Mews, Makaela A   +5 more
core   +1 more source

Age-disproportionate atrophy in Alzheimer's disease and Parkinson's disease spectra [PDF]

INTRODUCTION: Brain age gap (BAG), defined as the difference between MRI-predicted ‘brain age’ and chronological age, can capture information underlying various neurological disorders. We investigated the pathophysiological significance of the BAG across
Nobuo Fuse, Matsushima, Toma, Teruyuki Matsuoka, Takamura, Tsunehiko, Toma Matsushima, Kazuaki Kanai, Hanakawa, Takashi, Kanai, Kazuaki, Toshiya Murai, Noritaka Wakasugi, Mugikura, Shunji, Yoshinaga, Kenji, Atsushi Sekiguchi, Mitsunari Abe, Hiroshi Hoshino, Hoshino, Hiroshi, Murai, Toshiya, Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMMbMRI)Parkinson's and Alzheimer's disease Dimensional Neuroimaging Initiative (PADNI), Wakasugi, Noritaka, Nobukatsu Sawamoto, Toshiki Mizuno, Takashi Hanakawa, Togo, Hiroki, Kenji Yoshinaga, Shunji Mugikura, Sawamoto, Nobukatsu, Mizuno, Toshiki, Matsuoka, Teruyuki, Hiroki Togo, Tsunehiko Takamura, Abe, Mitsunari, Fuse, Nobuo, Sekiguchi, Atsushi   +32 more
core   +1 more source

Changes in Alzheimer's disease blood biomarkers in kidney failure before and after kidney transplant

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Alzheimer's disease (AD) blood biomarkers show promise for clinical diagnosis but their reliability in chronic kidney disease (CKD) is debated. This study investigates the impact of kidney transplant (KT) on AD biomarkers in CKD.
Anneka E. Blankenship, Lauren Yoksh, Paul J. Kueck, Jonathan D. Mahnken, Jill K. Morris, Aditi Gupta   +5 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Cannabinoids and Alzheimer's disease

, 2017
Alzheimer's disease is a neurodegenerative disease which is characterized by significant cognitive decline, physical, and behavioral impairment. Marijuana and associated derivatives of cannabis sativa plant are currently under limited investigation as ...
Raif, Daniel
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Early Recognition of Treatment‐Responsive Rapidly Progressive Dementia: The Modified STAM3mP Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Early identification of patients with treatment‐responsive rapidly progressive dementia (RPD) is important as early treatment improves outcomes. The STAM3P score identifies treatment‐responsive RPD using “high risk” presenting features. We optimized performance by adding a time component (i.e., dementia within 3 months) and validated the ...
R. W. van Steenhoven, N. Satyadev, A. E. M. Bastiaansen, Y. D. Piura, J. Kerstens, Y. S. Crijnen, J. Brenner, T. Brand, T. M. Bienfait, S. Veenbergen, J. M. de Vries, F. J. de Jong, E. G. P. Dopper, P. A. E. Sillevis Smitt, H. Seelaar, G. S. Day, M. J. Titulaer   +16 more
wiley   +1 more source

Fiscal Year 2014

, 2014
Annual financial report of the Texas Council on Alzheimer's Disease and Related Disorders documenting income, expenditures, and other relevant financial information for fiscal year ...
Texas Council on Alzheimer's Disease & Related Disorders
core