Results 131 to 140 of about 340,510 (279)

Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1‐42 in Alzheimer's Disease Neuroimaging Initiative participants

, 2017
Introduction Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid β (Aβ) 1-42 is an important Alzheimer's disease biomarker.
Sujuan Gao, Risacher, Shannon L., Li, Wei, Jeffrey S. Elmendorf, Gao, Sujuan, Stephen L. Boehm, Saykin, Andrew J., null null, Boehm, Stephen L., Shannon L. Risacher, Wei Li, Andrew J. Saykin, Elmendorf, Jeffrey S.   +12 more
core   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Epidemiology of dementia in Sao Paulo, Brazil: risk factors and age of onset of dementia due to Alzheimer's disease [PDF]

, 2012
The objective of this paper is to investigate the impact of previously reported sporadic risk factors over the age of onset of Alzheimer's disease in a Brazilian sample.
Chen, Elizabeth Suchi [UNIFESP], Oliveira, Fabricio Ferreira de [UNIFESP], Bertolucci, Paulo Henrique Ferreira [UNIFESP], Smith, Marilia de Arruda Cardoso [UNIFESP]   +3 more
core  

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217- after adjusting for initial learning strength

Frontiers in Neurology
BackgroundSemantic intrusion errors (SIEs) are associated with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). It is unknown whether accounting for maximum learning capacity still leads to an increase in SIEs when elevated plasma p ...
Rosie E. Curiel Cid, Rosie E. Curiel Cid, David Vaillancourt, David Vaillancourt, Alexandra Ortega, Alexandra Ortega, Elizabeth A. Crocco, Elizabeth A. Crocco, Kirsten Crenshaw, Kirsten Crenshaw, Stephanie M. Remedios, Breton M. Asken, Breton M. Asken, Melissa J. Armstrong, Melissa J. Armstrong, Idaly Velez Uribe, Idaly Velez Uribe, Wei-en Wang, Wei-en Wang, Monica Rosselli, Monica Rosselli, Malek Adjouadi, Malek Adjouadi, Michael Marsiske, Michael Marsiske, Warren W. Barker, Warren W. Barker, Steven DeKosky, Steven DeKosky, Glenn Smith, Glenn Smith, Ranjan Duara, Ranjan Duara, David A. Loewenstein, David A. Loewenstein   +34 more
doaj   +1 more source

Bias‐Field Free Single‐Frequency CW‐ODMR of Nitrogen‐Vacancy Centers in Diamond for the Detection of Transient Electrical Signals

Advanced Materials Interfaces, EarlyView.
Simplified quantum sensing technique for the detection of short electrical signals occurring in neuronal signaling or bioinspired technologies. We demonstrate a single frequency continuous‐wave optically detected magnetic resonance (CW‐ODMR) approach to sense signals that can be as short as 0.2 ms.
João Paulo Silva, Orlando D. Cunha, Pedro Magalhães, Filipe Camarneiro, Jana B. Nieder   +4 more
wiley   +1 more source

Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease

, 2016
The immune response in Alzheimer's disease (AD) involves activation of microglia which may remove amyloid-β (Aβ). However, overproduction of inflammatory compounds may exacerbate neural damage in AD.
Melah, Kelsey E, Blennow, Kaj,, Bratzke, Lisa C, Rowley, Howard A, Adluru, Nagesh, Carlsson, Cynthia M, Zetterberg, Henrik,, Sager, Mark A, Asthana, Sanjay, Lu, Sharon Yuan-Fu, Johnson, Sterling C, Destiche, Daniel J, Alexander, Andrew L, Hoscheidt, Siobhan M, Okonkwo, Ozioma C, Dowling, N Maritza, Gleason, Carey E, Bendlin, Barbara B   +17 more
core   +1 more source

Developing a Functional Polyelectrolyte Hybrid Layer Scaffold Coating and Evaluation of Its Performance for Interaction With Neural Cells

Advanced Materials Interfaces, EarlyView.
Polyelectrolyte scaffold coatings modified with Cu and Fe3O4 nanoparticles regulate neural stem cell behavior in vitro. Increased Fe3O4 content enhances mitochondrial activity and neuronal differentiation, whereas higher Cu levels reduce cell viability.
Anna Grzeczkowicz, Agata Lipko, Angelika Kwiatkowska, Marcin Strawski, Monika Drabik, Ludomira H. Granicka   +5 more
wiley   +1 more source

Associations between APOE‐TOMM40 ‘523 haplotypes and limbic system white matter microstructure

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION We assessed associations between apolipoprotein E Translocase of Outer Mitochondrial Membrane 40 (APOE‐TOMM40)‐‘523 haplotypes and white matter microstructure (WMM) across limbic tracts important for memory and cognition in non‐Hispanic ...
Katelyn E. Mooney, Derek B. Archer, Aditi Sathe, Timothy J. Hohman, Ose Kadiri, Melissa Lamar, Konstantinos Arfanakis, Lei Yu, Lisa L. Barnes, Kacie D. Deters   +9 more
doaj   +1 more source