Results 91 to 100 of about 340,510 (279)

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

A multi-cohort study of longitudinal and cross-sectional Alzheimer's disease biomarkers in cognitively unimpaired older adults [Elektronisk resurs]

INTRODUCTION: The generalizability of neuroimaging and cognitive biomarkers in their sensitivity to detect preclinical Alzheimer's disease (AD) and power to predict progression in large, multisite cohorts remains unclear.
Alzheimer's Disease Neuroimaging Initiative (ADNI), Wisse, Laura E.M.,, Lund University.   +2 more
core   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source

A Genomic Search for Alzheimer's Disease Genes

, 2001
Alzheimer's disease is the leading cause of dementia in the elderly and the most common form of dementia occurring after the age of 40. Alzheimer's disease has a complex genetic etiology with a strong genetic component that likely involves both gene–gene
Saunders, Anne M, Grubber, Janet M, Hedges, Dale, West, Sandra, Conneally, P. Michael, Hall, Jenifer L, Vance, Jeffery M, Bailey, L. Renee, Haines, Jonathan L, Roses, Allen D, Pericak‐Vance, Margaret A, Scott, William K, Kemmerer, Beth, Small, Gary W, Santoro, Leonard   +14 more
core   +1 more source

A retrospective analysis of serious adverse events and deaths in U.S.-based lifestyle clinical trials for cognitive health

Contemporary Clinical Trials Communications
Objective: This retrospective analysis examined serious adverse events (SAEs) and deaths in U.S. lifestyle clinical trials aimed at enhancing cognitive health in older adults.
Mickeal N. Key, Ashley R. Shaw, Kirk I. Erickson, Jeffrey M. Burns, Eric D. Vidoni   +4 more
doaj   +1 more source

Thioredoxin‐80 is a product of alpha‐secretase cleavage that inhibits amyloid‐beta aggregation and is decreased in Alzheimer's disease brain

EMBO Molecular Medicine, 2012
Thioredoxin‐1 (Trx1) is an endogenous dithiol reductant and antioxidant that was shown to be decreased in Alzheimer's disease (AD) neurons. A truncated form of Trx1, thioredoxin 80 (Trx80), was reported to be secreted from monocytes having cytokine ...
Francisco Gil‐Bea, Susanne Akterin, Torbjörn Persson, Laura Mateos, Anna Sandebring, Javier Avila‐Cariño, Angel Gutierrez‐Rodriguez, Erik Sundström, Arne Holmgren, Bengt Winblad, Angel Cedazo‐Minguez   +10 more
doaj   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Handbook of infection and Alzheimer's disease Advances in Alzheimer's disease (Series) ;, v. 5./ edited by Judith Miklossy.

, 2017
Includes bibliographical references and index.Section 1. A neglected side of Alzheimer's research -- Section 2. Inflammation and Alzheimer's disease -- Section 3. Bacterial infection and Alzheimer's disease -- Section 4.
Miklossy Judith
core  

Place cell physiology in a transgenic mouse model of Alzheimer's disease [PDF]

, 2009
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairments (Selkoe, 2001). Hippocampal place cells are a well understood candidate for the neural basis of one type of memory in rodents ...
Ming Yi, Yi, M., Yi, M
core  

Frontolimbic atrophy is associated with agitation and aggression in mild cognitive impairment and Alzheimer's disease

, 2013
Background: The neuroanatomy of agitation and aggression in Alzheimer's disease is not well understood. Methods: We analyzed 24 months of Alzheimer's Disease Neuroimaging Initiative data for patients with Alzheimer's disease, mild cognitive impairment ...
Yu, Peng, Tabas, Linda, Saykin, Andrew J., Alzheimer's Disease Neuroimaging Initiative, Forrester, Tammy, Trzepacz, Paula T., Bhamidipati, Phani K., Willis, Brian, Schwarz, Adam J.   +8 more
core   +1 more source