Results 91 to 100 of about 5,103,561 (270)

Metabolic and renal factors associated with plasma phosphorylated tau analytes used to detect Alzheimer's disease pathology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Introduction We examined the extent to which insulin resistance (IR), type 2 diabetes mellitus, obesity, and kidney function are associated with plasma phosphorylated tau (p‐tau) concentrations (p‐tau181, p‐tau217, p‐tau231) in the same cohort and the ...
Kao Lee Yang, Yue Ma, Gilda Ennis, Erin Jonaitis, Ramiro Eduardo Rea Reyes, Sterling C. Johnson, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Barbara B Bendlin   +9 more
doaj   +1 more source

Alzheimer Disease [PDF]

Continuum, 2016
This article discusses the recent advances in the diagnosis and treatment of Alzheimer disease (AD).In recent years, significant advances have been made in the fields of genetics, neuroimaging, clinical diagnosis, and staging of AD. One of the most important recent advances in AD is our ability to visualize amyloid pathology in the living human brain ...
openaire   +3 more sources

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

A multi-cohort study of longitudinal and cross-sectional Alzheimer's disease biomarkers in cognitively unimpaired older adults [Elektronisk resurs]

INTRODUCTION: The generalizability of neuroimaging and cognitive biomarkers in their sensitivity to detect preclinical Alzheimer's disease (AD) and power to predict progression in large, multisite cohorts remains unclear.
Alzheimer's Disease Neuroimaging Initiative (ADNI), Wisse, Laura E.M.,, Lund University.   +2 more
core   +1 more source

A service‐oriented approach to clinical trial recruitment for dementia and brain health: Methods and case examples of MyAlliance for Brain Health

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Recruitment of sufficient and diverse participants into clinical research for Alzheimer's disease and related dementias remains a formidable challenge.
Eric D. Vidoni, Emma Swinford, Kelli Barton, Jaime Perales‐Puchalt, C. Michelle Niedens, Tina Lewandowski, Tiffany Schwasinger‐Schmidt, Jill Peltzer, JoEllen Wurth, Jannette Berkley‐Patton, Ryan A. Townley, W. Todd Moore, Ashley R. Shaw, Mickeal N. Key, Erica Andrade, Melissa Robinson, Susan Sprague, Aiden Bondurant, Debra Brook, Jennifer Freund, Jeffrey M. Burns   +20 more
doaj   +1 more source

Alzheimer's disease [PDF]

BMJ, 1994
M, Owen, M, Liddell, P, McGuffin
openaire   +2 more sources

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Handbook of infection and Alzheimer's disease Advances in Alzheimer's disease (Series) ;, v. 5./ edited by Judith Miklossy.

, 2017
Includes bibliographical references and index.Section 1. A neglected side of Alzheimer's research -- Section 2. Inflammation and Alzheimer's disease -- Section 3. Bacterial infection and Alzheimer's disease -- Section 4.
Miklossy Judith
core  

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source