Results 81 to 90 of about 5,103,561 (270)

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Alzheimer's disease theranostics /

, 2019
Online resource; title from PDF title page (EBSCO, viewed January 31, 2019)Front Cover; Alzheimer's Disease Theranostics; Alzheimer's Disease Theranostics; Copyright; Dedication; Biography; Acknowledgements; Contents; 1 -- Introduction: Alzheimer's ...
Obulesu, Magisetty.
core  

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

Neurobiology of Disease, 2013
Deposition of amyloid β (Aβ) containing plaques in the brain is one of the neuropathological hallmarks of Alzheimer's disease (AD). It has been suggested that modulation of neuronal activity may alter Aβ production in the brain.
Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M. Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T. Hyman, Oksana Berezovska   +9 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Journal of Alzheimer's Disease

, 2019
The Journal of Alzheimer's Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
Lorenzo Falsetti
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Lessons from Multicenter Studies on CSF Biomarkers for Alzheimer's Disease [PDF]

, 2010
Several single-center studies have confirmed the usability of cerebrospinal fluid (CSF) biomarkers for the diagnosis of Alzheimer's disease (AD), even in early disease stages. Large scale multicenter studies have principally confirmed this, although such
Henrik Zetterberg, Blennow, Kaj,, Zetterberg, Henrik,, kaj Blennow, Niklas Mattsson, Mattsson, Niklas,   +5 more
core   +1 more source

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

Biomarkers in Alzheimer's disease /

, 2016
Print version record.Cover ; Title page; Copyright page; Contents; Foreword; Preface; Acknowledgments; Chapter 1 -- Introduction to Alzheimer's Disease Biomarkers ; 1.1 -- Historical Background; 1.2 -- Important Events in Alzheimer's Disease (AD ...
Khan, T. K.
core  

DOMINO-AD protocol : donepezil and memantine in moderate to severe Alzheimer's disease – a multicentre RCT [PDF]

, 2009
Background: Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glutamate antagonist memantine has
Ashley Baldwin, Ajay Macharouthu, Juszczak, E, R. Brown (3682735), Raftery, James, Jones Rob, Gray, R, Ballard, C, Burns, Alistair; id_orcid, Adams, Jessica, Knapp, M, Raftery James, J. Adams (7579901), Knapp, Martin, Griffin Mary, Ian McKeith, Baldwin, A, P. Passmore (7608800), Dening, Tom, Griffin, M, S. Banerjee (1503751), B. Sheehan (7608761), Jones Roy, Jones, Roy, T. Dening (7608776), Sube Banerjee, Sheehan, Bart, McShane, R, Patrick Phillips, Bentham, Peter, Findlay David, O'Brien, John, Alistair Burns, Barber, Bob, McShane, Rupert, Brown, R, Ritchie Craig, Dening, T, Hughes, Alan, J. Raftery (7608803), O'Brien John, Richard Brown, Holmes, C, Jessica Adams, Jacoby, Robin, Phillips, Patrick, McShane Rupert, Dening Tom, Clive Holmes, D. Findlay (7608779), Ballard Clive, Bart Sheehan, Rob Jones, Raftery, J, Brown, R. G., McKeith, I, Ritchie, C. W., A. Baldwin (7608767), Ritchie, Craig, P. Phillips (5239541), DOMINO-AD team, Banerjee, S, Ed Juszczak, P. Bentham (7589273), Juszczak, Ed, James. Lindesay (7608785), Robin Jacoby, Alan Hughes, Bob Barber, Richard Gray, Barber, B, Tony Johnson, Knapp Martin, Baldwin Ashley, Clive Ballard, Peter Bentham, Brown, Richard, McKeith, Ian, Brown, Richard; id_orcid, Juszczak Ed, Phillips Patrick, James Raftery, E. Juszczak (7589267), Burns, A, Howard Rob, Banerjee, Sube, Macharouthu, Ajay, Passmore, P, Brown Richard, Jones, R, Hughes Alan, Gray, Richard, Phillips, P, R. Jacoby (7589288), J. O'Brien (7608797), Phillips, P., Macharouthu Ajay, A. Burns (842688), R. Howard (1274091), Juszczak, Edmund, C. Holmes (7589285), Howard, Rob, M. Griffin (3933326), Macharouthu, A, M. Knapp (2534038), Jones, R. G., C. Ballard (7608770), Passmore, Peter, Johnson, T, Rob Howard, Holmes Clive, Sheehan Bart, Findlay, David, Rupert McShane, Jacoby, R, James Lindesay, Johnson, T., Hughes, A., Craig Ritchie, Howard, Robert, Jones, Roy W., O'Brien, J. T., David Findlay, R. McShane (7608791), Howard, R, Tom Dening, Onions Caroline, Holmes, Clive, McKeith Ian, Lindesay, J, Johnson Tony, Gray Richard, Barber Bob, I. McKeith (7608788), Ritchie, C, Burns Alistair, Adams, J., T. Johnson (7602368), A. Macharouthu (7608794), Johnson, Tony, Lindesay James, McKeith, I. G., A. Hughes (7190519), Jones, Rob, Banerjee Sube, Bentham Peter, Hughes, A, Lindesay, James, Raftery, J. P., Adams Jessica, Mary Griffin, Onions, Caroline, Griffin, Mary, C. Ritchie (7608806), Onions, C, Peter Passmore, John O'Brien, Baldwin, Ashley, Sheehan, B, Adams, J, Burns, Alistair, Jacoby Robin, Burns, Alistair S., Griffin, M., Passmore Peter, Roy Jones, R. Jones (3979994), Ballard, Clive, C. Onions (7608764), Bentham, P, Findlay, D, O'Brien, J, B. Barber (7608773), R. Gray (7608782), Martin Knapp, Caroline Onions   +175 more
core   +3 more sources