Results 61 to 70 of about 340,510 (279)

DOMINO-AD protocol : donepezil and memantine in moderate to severe Alzheimer's disease – a multicentre RCT [PDF]

, 2009
Background: Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glutamate antagonist memantine has
Ashley Baldwin, Ajay Macharouthu, Juszczak, E, R. Brown (3682735), Raftery, James, Jones Rob, Gray, R, Ballard, C, Burns, Alistair; id_orcid, Adams, Jessica, Knapp, M, Raftery James, J. Adams (7579901), Knapp, Martin, Griffin Mary, Ian McKeith, Baldwin, A, P. Passmore (7608800), Dening, Tom, Griffin, M, S. Banerjee (1503751), B. Sheehan (7608761), Jones Roy, Jones, Roy, T. Dening (7608776), Sube Banerjee, Sheehan, Bart, McShane, R, Patrick Phillips, Bentham, Peter, Findlay David, O'Brien, John, Alistair Burns, Barber, Bob, McShane, Rupert, Brown, R, Ritchie Craig, Dening, T, Hughes, Alan, J. Raftery (7608803), O'Brien John, Richard Brown, Holmes, C, Jessica Adams, Jacoby, Robin, Phillips, Patrick, McShane Rupert, Dening Tom, Clive Holmes, D. Findlay (7608779), Ballard Clive, Bart Sheehan, Rob Jones, Raftery, J, Brown, R. G., McKeith, I, Ritchie, C. W., A. Baldwin (7608767), Ritchie, Craig, P. Phillips (5239541), DOMINO-AD team, Banerjee, S, Ed Juszczak, P. Bentham (7589273), Juszczak, Ed, James. Lindesay (7608785), Robin Jacoby, Alan Hughes, Bob Barber, Richard Gray, Barber, B, Tony Johnson, Knapp Martin, Baldwin Ashley, Clive Ballard, Peter Bentham, Brown, Richard, McKeith, Ian, Brown, Richard; id_orcid, Juszczak Ed, Phillips Patrick, James Raftery, E. Juszczak (7589267), Burns, A, Howard Rob, Banerjee, Sube, Macharouthu, Ajay, Passmore, P, Brown Richard, Jones, R, Hughes Alan, Gray, Richard, Phillips, P, R. Jacoby (7589288), J. O'Brien (7608797), Phillips, P., Macharouthu Ajay, A. Burns (842688), R. Howard (1274091), Juszczak, Edmund, C. Holmes (7589285), Howard, Rob, M. Griffin (3933326), Macharouthu, A, M. Knapp (2534038), Jones, R. G., C. Ballard (7608770), Passmore, Peter, Johnson, T, Rob Howard, Holmes Clive, Sheehan Bart, Findlay, David, Rupert McShane, Jacoby, R, James Lindesay, Johnson, T., Hughes, A., Craig Ritchie, Howard, Robert, Jones, Roy W., O'Brien, J. T., David Findlay, R. McShane (7608791), Howard, R, Tom Dening, Onions Caroline, Holmes, Clive, McKeith Ian, Lindesay, J, Johnson Tony, Gray Richard, Barber Bob, I. McKeith (7608788), Ritchie, C, Burns Alistair, Adams, J., T. Johnson (7602368), A. Macharouthu (7608794), Johnson, Tony, Lindesay James, McKeith, I. G., A. Hughes (7190519), Jones, Rob, Banerjee Sube, Bentham Peter, Hughes, A, Lindesay, James, Raftery, J. P., Adams Jessica, Mary Griffin, Onions, Caroline, Griffin, Mary, C. Ritchie (7608806), Onions, C, Peter Passmore, John O'Brien, Baldwin, Ashley, Sheehan, B, Adams, J, Burns, Alistair, Jacoby Robin, Burns, Alistair S., Griffin, M., Passmore Peter, Roy Jones, R. Jones (3979994), Ballard, Clive, C. Onions (7608764), Bentham, P, Findlay, D, O'Brien, J, B. Barber (7608773), R. Gray (7608782), Martin Knapp, Caroline Onions   +175 more
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Association between BrainAGE and Alzheimer's disease biomarkers

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION The brain age gap estimation (BrainAGE) method uses a machine learning model to generate an age estimate from structural magnetic resonance imaging (MRI) scans. The goal was to study the association of brain age with Alzheimer's disease (AD)
Yousaf Abughofah, Rachael Deardorff, Aaron Vosmeier, Savannah Hottle, Jeffrey L. Dage, Desarae Dempsey, Liana G. Apostolova, Jared Brosch, David Clark, Martin Farlow, Tatiana Foroud, Sujuan Gao, Sophia Wang, Henrik Zetterberg, Kaj Blennow, Andrew J. Saykin, Shannon L. Risacher   +16 more
doaj   +1 more source

Characterizing biomarker features of cognitively normal individuals with ventriculomegaly

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction The clinical significance of ventriculomegaly in cognitively normal elderly individuals remains unclear. Methods We selected cognitively normal individuals (n = 425) from the Alzheimer's Disease Neuroimaging Initiative database and ...
Xiaofeng Li, Maowen Ba, Kok Pin Ng, Sulantha Mathotaarachchi, Tharick A. Pascoal, Pedro Rosa‐Neto, Serge Gauthier, Alzheimer's Disease Neuroimaging Initiative   +7 more
doaj   +1 more source

Insulin resistance is related to cognitive decline but not change in CSF biomarkers of Alzheimer's disease in non‐demented adults

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction We investigated whether insulin resistance (IR) was associated with longitudinal age‐related change in cognition and biomarkers of Alzheimer's disease (AD) pathology and neurodegeneration in middle‐aged and older adults who were non‐demented
Gilda E. Ennis, Rebecca L. Koscik, Yue Ma, Erin M. Jonaitis, Carol A. Van Hulle, Tobey J. Betthauser, Allison M. Randall, Nathaniel Chin, Corinne D. Engelman, Rozalyn Anderson, Ivonne Suridjan, Gwendlyn Kollmorgen, Bradley T. Christian, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B. Bendlin   +18 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Cognitive decline across five cognitive batteries: Sample size implications for clinical trials

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION We evaluated the statistical power for a theoretical randomized trial of anti‐amyloid treatment in preclinical Alzheimer's Disease across five cognitive composites in preclinical Alzheimer's Disease across five cognitive composites ...
Andrea R. Zammit, Ana W. Capuano, Lisa L. Barnes, Julie A. Schneider, Reisa A. Sperling, David A. Bennett, Francine Grodstein   +6 more
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

Neurobiology of Disease, 2013
Deposition of amyloid β (Aβ) containing plaques in the brain is one of the neuropathological hallmarks of Alzheimer's disease (AD). It has been suggested that modulation of neuronal activity may alter Aβ production in the brain.
Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M. Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T. Hyman, Oksana Berezovska   +9 more
doaj   +1 more source