Results 51 to 60 of about 5,103,561 (270)

Association between trust of researchers and willingness to participate in Alzheimer's disease biomarker research

Alzheimer’s & Dementia: Behavior & Socioeconomics of Aging
Introduction The study examined the relationship between trust of researchers in research‐naïve participants, including those at higher risk, and interest in Alzheimer's disease and related dementias (ADRD) biomarker research participation.
Laureen Raelly‐Muze, Taylor Etchison, Adele Crouch, Johanne Eliacin, Angelina Polsinelli, Sujuan Gao, Sarah Van Heiden, Joseph Asper, Caprice Elliott, Ralph Richards, Mollie Richards, Christopher Campbell, Hugh Hendrie, Pamella Shaw, Omolola Adeoye‐Olatunde, Shannon Risacher, Andrew Saykin, Sophia Wang   +17 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Mitochondrial blood‐based biomarker is related to cardiorespiratory fitness and aging in a sex‐dependent manner

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION A sedentary lifestyle increases the risk for Alzheimer's disease (AD), whereas exercise has been shown to benefit brain health. Physiological factors, such as female sex, are linked to lower cardiorespiratory fitness and can increase the ...
Riley E. Kemna, Amanda Szabo‐Reed, Hana D. Mayfield, Paul J. Kueck, Jenae Pennington, Casey S. John, Brittany M. Hauger, Heather M. Wilkins, Eric D. Vidoni, Jill K. Morris   +9 more
doaj   +1 more source

Differential effects of neurodegeneration biomarkers on subclinical cognitive decline

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019
Introduction Neurodegeneration appears to be the biological mechanism most proximate to cognitive decline in Alzheimer's disease. We test whether t‐tau and alternative biomarkers of neurodegeneration—neurogranin and neurofilament light protein (NFL)—add ...
Andrew P. Merluzzi, Nicholas M. Vogt, Derek Norton, Erin Jonaitis, Lindsay R. Clark, Cynthia M. Carlsson, Sterling C. Johnson, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin   +10 more
doaj   +1 more source

Visualization of PS/γ-Secretase Activity in Living Cells

iScience, 2020
Summary: A change in Presenilin (PS)/γ-secretase activity is linked to essential biological events as well as to the progression of many diseases. However, not much is known about how PS/γ-secretase activity is spatiotemporally regulated in cells. One of
Masato Maesako, Nicole M. Sekula, Anna Aristarkhova, Polina Feschenko, Lauren C. Anderson, Oksana Berezovska   +5 more
doaj   +1 more source

A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data.

, 2019
INTRODUCTION:Characterizing progression in Alzheimer's disease is critically important for early detection and targeted treatment. The objective was to develop a prognostic model, based on multivariate longitudinal markers, for predicting progression ...
Alzheimer's Disease Neuroimaging Initiative, Lutz, Michael, Li, Kan, Luo, Sheng, O'Brien, Richard   +4 more
core   +1 more source

Journal of Alzheimer's Disease

, 2018
The Journal of Alzheimer's Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's ...
Falsetti L
core   +1 more source

Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism

Disease Models & Mechanisms, 2022
Energy production is the most fundamentally important cellular activity supporting all other functions, particularly in highly active organs, such as brains.
Karissa Barthelson, Morgan Newman, Michael Lardelli   +2 more
doaj   +1 more source

Alzheimer's disease

The Lancet, 2021
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The most recent data indicate that, by 2050, the prevalence of dementia will double in Europe and triple worldwide, and that estimate is 3 times higher when based on a biological (rather than clinical) definition of Alzheimer's disease.
Scheltens, Philip, De Strooper, Bart, Kivipelto, Miia, Holstege, Henne, Chetelat, Gael, Teunissen, Charlotte E., Cummings, Jeffrey, van der Flier, Wiesje M.   +7 more
openaire   +4 more sources