Results 71 to 80 of about 340,510 (279)

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?

, 2006
Background: There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied.
Smith, AD, Horton Roger, Barnardo Martin CNM, Stephan Beck, Warden Donald R, Warden, DR, Martin CNM Barnardo, Barnetson, L, Smith A David, Andrew Sutherland, Lehmann, DJ, Beck Stephan, Barnardo, MC, Isabel Quiroga, Fuggle Susan, Barnetson Lin, Barnardo, MCNM, Quiroga Isabel, Lehmann Donald J, Roger Horton, Beck, S, Susan Fuggle, Donald R Warden, Fuggle, S, Sutherland Andrew, Sutherland, A, Donald J Lehmann, Lin Barnetson, A David Smith, Quiroga, I, Horton, R   +30 more
core   +1 more source

Lessons from Multicenter Studies on CSF Biomarkers for Alzheimer's Disease [PDF]

, 2010
Several single-center studies have confirmed the usability of cerebrospinal fluid (CSF) biomarkers for the diagnosis of Alzheimer's disease (AD), even in early disease stages. Large scale multicenter studies have principally confirmed this, although such
Henrik Zetterberg, Blennow, Kaj,, Zetterberg, Henrik,, kaj Blennow, Niklas Mattsson, Mattsson, Niklas,   +5 more
core   +1 more source

Associations of renin–angiotensin system inhibitor use with brain insulin signaling and neuropathology

Annals of Clinical and Translational Neurology
Objective To examine the associations of renin–angiotensin system (RAS) inhibitor use with postmortem brain insulin signaling and neuropathology. Methods Among Religious Orders Study participants, 150 deceased and autopsied older individuals (75 with ...
Han Tong, Ana W. Capuano, Rupal I. Mehta, Ajay Sood, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis   +7 more
doaj   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Alzheimer Disease [PDF]

Continuum, 2016
This article discusses the recent advances in the diagnosis and treatment of Alzheimer disease (AD).In recent years, significant advances have been made in the fields of genetics, neuroimaging, clinical diagnosis, and staging of AD. One of the most important recent advances in AD is our ability to visualize amyloid pathology in the living human brain ...
openaire   +3 more sources

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration. [PDF]

, 2013
OBJECTIVE: To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD).
Manning, Emily N, Manning, EN, Leung, Kelvin K, Leung, Kelvin K., Bartlett, Jonathan W., Fox, Nick C, Fox, Nick C., Barnes, Josephine, Ourselin, Sebastien, Alzheimer's Disease Neuroimaging Initiative, Bartlett, Jonathan W, Bartlett, JW, Ourselin, S, Fox, NC, Manning, Emily N., Barnes, J, Leung, KK   +16 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

The complementary role of automated brain volumetry to stratify ADNI participants within the ATN framework

The amyloid, tau, neurodegeneration (ATN) framework provides a biological staging model of Alzheimer's disease (AD) using magnetic resonance imaging (MRI), cerebrospinal fluid (CSF), or positron emission tomography (PET) biomarkers.
Corredor-Jerez, Ricardo, Maréchal, B., Démonet, Jean-François, Griffa, A., Griffa, Alessandra, Démonet, J.F., Ricchi, Ilaria, Ricchi, I., Rouaud, Olivier, Allali, Gilles, Maréchal, Bénédicte, Corredor-Jerez, R., Richiardi, J., Rouaud, O., Richiardi, Jonas, Allali, G.   +15 more
core   +1 more source