Results 231 to 240 of about 472,310 (340)
Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques
The study constructs an in vitro Aβ plaque‐associated microglia model and uses SECM and SICM to in situ monitor changes in ROS levels, membrane permeability, and phagocytosis of microglia during Aβ clearance. It is found out that Aβ stiffness triggers microglial activation via the PIEZO1 mechanotransduction pathway, causing neuroinflammation and ...
Yulin Liu+8 more
wiley +1 more source
Ubiquitin-proteasome system in the different stages of dominantly inherited Alzheimer's disease. [PDF]
Liu H+36 more
europepmc +1 more source
Chromosome studies on four patients with Alzheimer's disease.
Tetsuji KADOTANI+5 more
openalex +2 more sources
Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang+16 more
wiley +1 more source
Correction to "Resistance and resilience to Alzheimer's disease in Down syndrome". [PDF]
europepmc +1 more source
Machine learning-enhanced screening funnel for clinical trials in Alzheimer's disease. [PDF]
Gladstein S+6 more
europepmc +1 more source
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai+20 more
wiley +1 more source
Near‐Freezing‐Temperature Golgi Neuronal Staining for X‐ray Imaging of Human Brain
A near‐freezing temperature staining strategy, combined with a mercury chloride‐based method, effectively preserves delicate neuronal structures in post‐mortem frozen human brain tissues by minimizing autolysis. This approach enables uniform labeling across centimeter‐scale slices and, when integrated with synchrotron‐based X‐ray microscopy, achieves ...
Feng Zhou+12 more
wiley +1 more source