Results 231 to 240 of about 472,310 (340)

Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques

open access: yesAdvanced Science, EarlyView.
The study constructs an in vitro Aβ plaque‐associated microglia model and uses SECM and SICM to in situ monitor changes in ROS levels, membrane permeability, and phagocytosis of microglia during Aβ clearance. It is found out that Aβ stiffness triggers microglial activation via the PIEZO1 mechanotransduction pathway, causing neuroinflammation and ...
Yulin Liu   +8 more
wiley   +1 more source

Ubiquitin-proteasome system in the different stages of dominantly inherited Alzheimer's disease. [PDF]

open access: yesAlzheimers Dement
Liu H   +36 more
europepmc   +1 more source

Chromosome studies on four patients with Alzheimer's disease.

open access: bronze, 1985
Tetsuji KADOTANI   +5 more
openalex   +2 more sources

Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix

open access: yesAdvanced Science, EarlyView.
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang   +16 more
wiley   +1 more source

Machine learning-enhanced screening funnel for clinical trials in Alzheimer's disease. [PDF]

open access: yesAlzheimers Dement (N Y)
Gladstein S   +6 more
europepmc   +1 more source

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats

open access: yesAdvanced Science, EarlyView.
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai   +20 more
wiley   +1 more source

THE ALZHEIMER’S DISEASE MULTIFACTORIAL THERAPEUTIC AGENT E2F4DN PREVENTS THE UPREGULATION OF THE PRO-DEATH GENE CITED 2 IN RESPONSE TO DNA DAMAGE IN NEURONS

open access: yesIBRO Neuroscience Reports, 2023
Aina Maria Llabrés Mas   +3 more
doaj  

Near‐Freezing‐Temperature Golgi Neuronal Staining for X‐ray Imaging of Human Brain

open access: yesAdvanced Science, EarlyView.
A near‐freezing temperature staining strategy, combined with a mercury chloride‐based method, effectively preserves delicate neuronal structures in post‐mortem frozen human brain tissues by minimizing autolysis. This approach enables uniform labeling across centimeter‐scale slices and, when integrated with synchrotron‐based X‐ray microscopy, achieves ...
Feng Zhou   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy