Results 231 to 240 of about 309,096 (319)
Advanced Science, EarlyView.This study examines the effects of Shank3 mutation on the mesoaccumbens pathway using a Shank3‐deficient rat model. The findings reveal altered social reward processing in these rats, accompanied by changes in dopaminergic and GABAergic neural activity within the ventral tegmental area (VTA) and dopamine release in the nucleus accumbense (NAc ...
Marie Barbier +4 more
wiley +1 more source
ALZHEIMER'S DISEASE: THE STANDARD REFERENCE. Edited by Barry Reisberg. Published by Collier MacMillan Canada Inc., 1983. 475 pages. Illustrated. $69.95 Cdn. [PDF]
, 1986 Irma M. Parhad
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Advanced Science, EarlyView.Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai +12 more
wiley +1 more source
Differential memory and executive functions in demented patients with Parkinson's and Alzheimer's disease. [PDF]
, 1991 Irene Litvan +4 more
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Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT
Advanced Science, EarlyView.Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li +8 more
wiley +1 more source
Human antibodies reactive with beta-amyloid protein in Alzheimer's disease. [PDF]
, 1993 Felicia Gaskin +4 more
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Advanced Science, EarlyView.Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang +4 more
wiley +1 more source