Results 231 to 240 of about 269,936 (310)
Clinically meaningful outcomes in Alzheimer's disease and Alzheimer's disease related dementias trials. [PDF]
Stoeckel LE+5 more
europepmc +1 more source
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves+17 more
wiley +1 more source
A compilation of reported alterations in the cerebrospinal fluid proteome in Alzheimer's disease. [PDF]
de Geus MB+3 more
europepmc +1 more source
Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang+16 more
wiley +1 more source
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai+20 more
wiley +1 more source
Multisystem failure, tipping points, and risk of Alzheimer's disease. [PDF]
Merlini S+3 more
europepmc +1 more source
Near‐Freezing‐Temperature Golgi Neuronal Staining for X‐ray Imaging of Human Brain
A near‐freezing temperature staining strategy, combined with a mercury chloride‐based method, effectively preserves delicate neuronal structures in post‐mortem frozen human brain tissues by minimizing autolysis. This approach enables uniform labeling across centimeter‐scale slices and, when integrated with synchrotron‐based X‐ray microscopy, achieves ...
Feng Zhou+12 more
wiley +1 more source