Results 221 to 230 of about 5,103,561 (270)

Stress, stress systems, and Alzheimer's disease. [PDF]

Alzheimers Dement
Eberly SG, Phumsatitpong C, Munro CE, Neylan TC, Kaufer D, Ehrenberg AJ.   +5 more
europepmc   +1 more source

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

Mechanisms, Biomarkers and Therapeutic Implications of Neuroinflammation in Alzheimer's Disease. [PDF]

Int J Dev Neurosci
Papelian S.
europepmc   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression. [PDF]

Alzheimers Dement
Lan G, Liao W, Jiang M, Zhu J, Ran W, Gonzalez-Ortiz F, Fan X, Yang H, Shi D, Zhang L, Li A, Cai Y, Sun P, He Z, Zhou X, Yang J, Zhu Y, Li M, Huang W, Liu B, Wang Y, Ma X, Ma R, Zhang Y, Huang C, Liu Z, Wang Q, Zhou L, Xie F, Han Y, Liang Z, Chen X, Dong M, Cheng G, Wang L, Luo B, Wang YJ, Chen X, Alzheimer's Disease Neuroimaging Initiative, Xin J, Peng G, Guo T.   +41 more
europepmc   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Health-related factors and their impact on blood-based biomarkers of Alzheimer's disease. [PDF]

Aging Brain
Kurz C, Taute M, Tegethoff P, Hufnagel A, Leonhardt S, Gürsel SÜ, Koriath C, Jethwa A, Kollmorgen G, Bittner T, Keeser D, Brendel M, Haeckert J, Utecht J, Papazov B, Levin J, Höglinger G, Rauchmann BS, Perneczky R.   +18 more
europepmc   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Digital cognitive phenotyping enhances risk stratification in preclinical Alzheimer's disease. [PDF]

Alzheimers Dement
Vanderlip CR, Stark CEL.
europepmc   +1 more source