Results 201 to 210 of about 5,103,561 (270)

When myelin breaks, tau aggregates - a new perspective on Alzheimer's disease. [PDF]

Alzheimers Dement
Tiane A, van den Hove D, Vanmierlo T.
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Choroid plexus volume in pathology-confirmed Alzheimer's disease. [PDF]

J Prev Alzheimers Dis
Fernandes F, Dey A, Ma A, Churchill NW, Fischer CE, Graham SJ, Munoz DG, Schweizer TA.   +7 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Speech-In-Noise Perception in Alzheimer's Disease and Primary Progressive Aphasia. [PDF]

Eur J Neurol
Froud SA, Levett BA, Jiang J, Core LB, Koohi N, Tutton M, Green T, Bamiou DE, Marshall CR, Hardy CJD, Warren JD.   +10 more
europepmc   +1 more source

Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease. [PDF]

J Alzheimers Dis
Eruysal E, Ravdin L, Iadecola C, Ishii M.   +3 more
europepmc   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Association of sleep duration with Alzheimer's disease and cognition. [PDF]

Alzheimers Dement
Anagnostakis F, O'Toole CK, Erus G, Srinivasan D, Cui Y, Kokkorakis M, Ma X, Reitz C, Brickman AM, Kontos D, Gupta A, Payabvash S, Konofagou EE, McIlvain G, Cheng F, Baldwin MR, Shou H, Davatzikos C, Resnick S, Wen J.   +19 more
europepmc   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Real-world implementation of lecanemab in Alzheimer's disease: A Japanese cohort. [PDF]

Alzheimers Dement (Amst)
Shimohama S, Bun S, Shikimoto R, Tomioka H, Takayama T, Mimura Y, Sasaguri H, Sekiguchi K, Nishimoto Y, Iwabuchi Y, Tabuchi H, Nakahara J, Mimura M, Ito D.   +13 more
europepmc   +1 more source