Results 211 to 220 of about 5,103,561 (270)

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

Transcriptional risk score for chronic kidney disease: relation to Alzheimer's disease. [PDF]

Alzheimers Dement
Pyun JM, Park YH, Hwang J, Kim S, Yi Y, Nho K, Alzheimer's Disease Neuroimaging Initiative.   +6 more
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Gantenerumab for Early Alzheimer's Disease: An Updated Systematic Review and Meta-Analysis. [PDF]

Brain Behav
Javed MN, Khan SM, Mustafa S, Mujtaba A, Amin H, Azhar N, Hameed A, Zayed A, Khalid M, Hussain JM.   +9 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Alzheimer's disease polygenic risk in early- and late-onset Alzheimer's disease. [PDF]

Alzheimers Dement
Pentchev JV, Jackson T, Khan N, Rosewood TJ, Huang YN, Nho K, Saykin AJ, Eloyan A, Taurone A, Thangarajah M, Riddle M, Salloway S, Atri A, Honig LS, Johnson ECB, Turner RS, Masdeu JC, Foroud TM, Clark D, Hammers DB, Dage JL, Kirby K, Ghetti B, Newell K, Onyike CU, Day GS, Graff-Radford NR, Murray ME, Jones DT, Jack CR, Vemuri P, Touroutoglou A, Duara R, Grant I, Sha S, Wingo TS, Beckett LA, Rogalski E, Mendez MF, Kramer J, La Joie R, Blazhenets G, Grinberg LT, Koeppe R, Wolk DA, Aisen P, Raman R, Toga A, Kukull WA, Musiek E, Womack KB, Carrillo MC, Rabinovici GD, Dickerson BC, Apostolova LG, Nudelman KNH, Longitudinal Early‐Onset Alzheimer's Disease Study Consortium and the Alzheimer's Disease Neuroimaging Initiative.   +56 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Genetic evidence suggests a protective role of immunoglobulin M in Alzheimer's disease. [PDF]

Alzheimers Dement
Peng S, Butler-Laporte G, Johnson SC, Engelman CD, Lu T.   +4 more
europepmc   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source