Results 211 to 220 of about 340,510 (279)

Current and Emerging Pharmacological Treatment Options for Dementia

Behavioural Neurology, 2006
John M. Ringman, Jeffrey L. Cummings
doaj   +1 more source

Minor neuropsychological deficits and stage 2 of Alzheimer's disease. [PDF]

Alzheimers Dement
Stark M, Wagner M, Kuhn E, Roeske S, Amthauer H, Bartels C, Boecker H, Brosseron F, Buchert R, Buerger K, Daamen M, Drzezga A, Düzel E, Ersözlü E, Essler M, Ewers M, Fliessbach K, Glanz W, Hellmann-Regen J, Incesoy EI, Janowitz D, Kafali K, Kilimann I, Krause BJ, Kronmüller M, Laske C, Maier F, Maurer A, Michely J, Perneczky R, Peters O, Preis L, Priller J, Rauchmann BS, Reimold M, Rominger A, Schmid M, Schneider A, Sodenkamp S, Spottke A, Spruth EJ, Teipel S, Wiltfang J, Alzheimer´s Disease Neuroimaging Initiative (ADNI), Jessen F, Kleineidam L.   +45 more
europepmc   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Amyloid-targeting treatment in Alzheimer's disease and concomitant antiplatelets: a clinical gray zone? [PDF]

Front Neurol
Rus Prelog P, Zupan M, Kovačič A, Frol S, Gregorič Kramberger M.   +4 more
europepmc   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

S4‐02‐01: Alzheimer's Disease Sequencing Project: Case‐Control Analyses

, 2016
Naj, Adam C., Kunkle, Brian, and the Alzheimer's Disease Sequencing Project, Martin, Eden   +3 more
core   +1 more source

Heritability of Alzheimer's disease-related plasma biomarkers in the Amish population. [PDF]

Alzheimers Dement (Amst)
Wang P, Song YE, Lynn A, Miskimen K, Gulyayev A, Prough MB, Dorfsman DA, Laux RA, Fuzzell SL, Hochstetler SD, Zaman AF, Adams LD, Caywood LJ, Clouse JE, Herington SD, Whitehead P, Liu Y, Moore N, Ogrocki P, Lerner AJ, Griswold AJ, Vance JM, Cuccaro ML, Scott WK, Pericak-Vance MA, Haines JL.   +25 more
europepmc   +1 more source

Machine Learning‐Enhanced Ultrasensitive Immuno‐CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers

Advanced Science, EarlyView.
This work presents a CRISPR‐based, ultrasensitive multiplex protein detection array capable of simultaneously analyzing six plasma biomarkers associated with Alzheimer's disease (AD). By integrating antibody‐mediated signal transduction, recombinase polymerase amplification, and spatially encoded CRISPR‐Cas12a, the system achieves detection sensitivity
Liding Zhang, Changwen Yang, Qian Yao, Xuewei Du, Shuai Ding, Yaoqiang Shi, Can Sheng, Ming Wang, Ying Han, Haiming Luo   +9 more
wiley   +1 more source