Results 231 to 240 of about 9,650,018 (348)

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer’s Disease

, 2015
Federica Prati, Angela De Simone, Andrea Armirotti, Maria Summa, Daniela Pizzirani, Rita Scarpelli, Sine Mandrup Bertozzi, Daniel I. Pérez, Vincenza Andrisano, Ana Pérez‐Castillo, Barbara Monti, Francesca Massenzio, Letizia Polito, Marco Racchi, Piera Sabatino, Giovanni Bottegoni, Ana Martı́nez, Andrea Cavalli, María Laura Bolognesi   +18 more
openalex   +2 more sources

Inflammation and Alzheimer’s disease

Neurobiology of Aging, 2000
H. Akiyama, S. Barger, S. Barnum, B. Bradt, J. Bauer, G. Cole, N. Cooper, P. Eikelenboom, M. Emmerling, B. Fiebich, C. Finch, S. Frautschy, W. Griffin, H. Hampel, M. Hull, G. Landreth, L. Lue, R. Mrak, I. Mackenzie, P. Mcgeer, M. O’Banion, J. Pachter, G. Pasinetti, C. Plata-salamán, J. Rogers, R. Rydel, Yong Shen, W. Streit, R. Strohmeyer, Ikuo Tooyoma, F. L. Muiswinkel, R. Veerhuis, D. Walker, S. Webster, Beatrice Wegrzyniak, G. Wenk, T. Wyss-Coray   +36 more
semanticscholar   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Cortical hypoperfusion and reduced cerebral metabolic rate of oxygen in the arcAβ mouse model of Alzheimer’s disease

, 2018
Ruiqing Ni, Markus Rudin, Jan Klohs
openalex   +1 more source

Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

New England Journal of Medicine, 2012
R. Bateman, C. Xiong, T. Benzinger, A. Fagan, A. Goate, Nick C Fox, D. Marcus, N. Cairns, Xianyun Xie, Tyler M. Blazey, D. Holtzman, A. Santacruz, V. Buckles, A. Oliver, K. Moulder, P. Aisen, B. Ghetti, W. Klunk, E. McDade, R. Martins, C. Masters, R. Mayeux, J. Ringman, M. Rossor, P. Schofield, R. Sperling, S. Salloway, J. Morris   +27 more
semanticscholar   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Microbial links to Alzheimer's disease. [PDF]

PLoS Pathog
Cornitius CP, Perez EK, Lee SC.
europepmc   +1 more source

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

Nature Reviews Neuroscience, 2011
B. Zlokovic
semanticscholar   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Cerebral Hypoperfusion and Other Shared Brain Pathologies in Ischemic Stroke and Alzheimer’s Disease

, 2017
Shuying Dong, Shelly Maniar, Mioara D. Manole, Dandan Sun   +3 more
openalex   +2 more sources