Results 241 to 250 of about 9,650,018 (348)
Nanoscale Mapping of the Subcellular Glycosylation Landscape
Advanced Science, EarlyView.Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski +4 morewiley +1 more sourceNDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo +18 morewiley +1 more sourceIron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke
Advanced Science, EarlyView.Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang +17 morewiley +1 more sourceGenetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Nature Genetics, 2019 B. Kunkle, B. Grenier‐Boley, R. Sims, J. Bis, V. Damotte, A. Naj, A. Boland, M. Vronskaya, S. J. van der Lee, A. Amlie-Wolf, C. Bellenguez, A. Frizatti, V. Chouraki, E. Martin, K. Sleegers, N. Badarinarayan, J. Jakobsdóttir, K. Hamilton-Nelson, S. Moreno-Grau, R. Olaso, R. Raybould, Yuning Chen, A. Kuzma, M. Hiltunen, T. Morgan, S. Ahmad, B. Vardarajan, J. Epelbaum, P. Hoffmann, M. Boada, G. Beecham, Jean-Guillaume Garnier, D. Harold, A. Fitzpatrick, O. Valladares, Marie-Laure Moutet, A. Gerrish, A. Smith, L. Qu, D. Bacq, N. Denning, X. Jian, Yi Zhao, M. Del Zompo, Nick C Fox, S. Choi, I. Mateo, J. T. Hughes, H. Adams, J. Malamon, F. Sánchez-García, Y. Patel, J. Brody, B. Dombroski, M. Naranjo, M. Daniilidou, G. Eiriksdottir, Shubhabrata Mukherjee, D. Wallon, J. Uphill, T. Aspelund, L. Cantwell, F. Garzia, D. Galimberti, E. Hofer, Mariusz Butkiewicz, B. Fin, E. Scarpini, C. Sarnowski, W. Bush, S. Meslage, J. Kornhuber, Charles C. White, Yuenjoo Song, R. Barber, S. Engelborghs, S. Sordon, D. Voijnovic, P. Adams, R. Vandenberghe, M. Mayhaus, L. Cupples, M. Albert, P. D. de Deyn, W. Gu, J. Himali, D. Beekly, A. Squassina, A. Hartmann, A. Orellana, D. Blacker, E. Rodríguez-Rodríguez, S. Lovestone, M. Garcia, R. Doody, Carmen Munoz-Fernadez, R. Sussams, Honghuang Lin, T. Fairchild, Y. A. Benito, C. Holmes, Hata Karamujić‐Čomić, M. Frosch, H. Thonberg, W. Maier, G. Roschupkin, B. Ghetti, V. Giedraitis, A. Kawalia, Shuo Li, R. Huebinger, L. Kilander, S. Moebus, I. Hernández, M. Kamboh, R. Brundin, J. Turton, Qiong Yang, M. Katz, L. Concari, J. Lord, A. Beiser, C. Keene, S. Helisalmi, I. Kloszewska, W. Kukull, A. Koivisto, A. Lynch, L. Tárraga, E. Larson, A. Haapasalo, B. Lawlor, T. Mosley, R. Lipton, V. Solfrizzi, M. Gill, W. Longstreth, T. Montine, V. Frisardi, M. Diez-Fairen, F. Rivadeneira, R. Petersen, V. Deramecourt, I. Álvarez, Francesca Salani, A. Ciaramella, E. Boerwinkle, E. Reiman, N. Fievet, J. Rotter, J. Reisch, O. Hanon, C. Cupidi, A. G. Andre Uitterlinden, D. Royall, C. Dufouil, R. Maletta, I. de Rojas, M. Sano, A. Brice, R. Cecchetti, P. George-Hyslop, K. Ritchie, M. Tsolaki, D. Tsuang, B. Dubois, D. Craig, Chuang‐Kuo Wu, H. Soininen, D. Avramidou, R. Albin, L. Fratiglioni, A. Germanou, L. Apostolova, L. Keller, M. Koutroumani, S. Arnold, F. Panza, O. Gkatzima, S. Asthana, D. Hannequin, P. Whitehead, C. Atwood, P. Caffarra, H. Hampel, I. Quintela, Á. Carracedo, L. Lannfelt, D. Rubinsztein, L. Barnes, F. Pasquier, L. Frölich, S. Barral, B. McGuinness, T. Beach, J. Johnston, J. Becker, P. Passmore, E. Bigio, J. Schott, T. Bird, J. Warren, B. Boeve, Michelle K. Lupton, J. Bowen, P. Proitsi, A. Boxer, J. Powell, J. Burke, J. Kauwe, J. Burns, M. Mancuso, J. Buxbaum, U. Bonuccelli, N. Cairns, A. McQuillin, C. Cao, G. Livingston, C. Carlson, N. Bass, C. Carlsson, J. Hardy, R. Carney, J. Bras, M. Carrasquillo, R. Guerreiro, M. Allen, H. Chui, E. Fisher, C. Masullo, E. Crocco, C. DeCarli, G. Bisceglio, M. Dick, Li Ma, R. Duara, N. Graff-Radford, Denis A. Evans, A. Hodges, K. Faber, M. Scherer, K. Fallon, M. Riemenschneider, D. Fardo, R. Heun, M. Farlow, H. Kölsch, S. Ferris, M. Leber, T. Foroud, I. Heuser, D. Galasko, I. Giegling, M. Gearing, M. Hüll, D. Geschwind, J. Gilbert, J. Morris, R. Green, K. Mayo, J. Growdon, T. Feulner, R. Hamilton, L. Harrell, D. Drichel, L. Honig, T. Cushion, M. Huentelman, P. Hollingworth, C. Hulette, B. Hyman, R. Marshall, G. Jarvik, A. Meggy, E. Abner, G. Menzies, Lee‐way Jin, G. Leonenko, L. Real, G. Jun, C. Baldwin, D. Grozeva, A. Karydas, G. Russo, J. Kaye, R. Kim, F. Jessen, N. Kowall, B. Vellas, J. Kramer, E. Vardy, F. LaFerla, K. Jöckel, J. Lah, M. Dichgans, J. Leverenz, D. Mann, A. Levey, S. Pickering-Brown, A. Lieberman, N. Klopp, K. Lunetta, H. Wichmann, C. Lyketsos, K. Morgan, D. Marson, K. Brown, F. Martiniuk, C. Medway, D. Mash, M. Nöthen, E. Masliah, N. Hooper, W. McCormick, A. Daniele, S. McCurry, A. Bayer, A. McDavid, J. Gallacher, A. Mckee, H. van den Bussche, M. Mesulam, C. Brayne, B. Miller, S. Riedel-Heller, C. Miller, Joshua W. Miller, A. Al-Chalabi, J. Morris, C. Shaw, A. Myers, J. Wiltfang, S. O'Bryant, J. Olichney, V. Álvarez, J. Parisi, A. Singleton, H. Paulson, J. Collinge, W. Perry, S. Mead, E. Peskind, D. Cribbs, M. Rossor, A. Pierce, N. Ryan, W. Poon, B. Nacmias, H. Potter, S. Sorbi, J. Quinn, E. Sacchinelli, A. Raj, G. Spalletta, M. Raskind, C. Caltagirone, P. Bossù, M. D. Orfei, B. Reisberg, R. Clarke, C. Reitz, A. Smith, J. Ringman, D. Warden, E. Roberson, G. Wilcock, E. Rogaeva, A. Bruni, H. Rosen, M. Gallo, R. Rosenberg, Y. Ben-Shlomo, M. Sager, P. Mecocci, A. Saykin, P. Pastor, M. Cuccaro, J. Vance, J. Schneider, L. S. Schneider, S. Slifer, W. Seeley, Amanda G. Smith, J. Sonnen, S. Spina, R. Stern, R. Swerdlow, Mitchell Tang, R. Tanzi, J. Trojanowski, J. Troncoso, V. V. Van Deerlin, L. V. Van Eldik, H. Vinters, J. Vonsattel, S. Weintraub, K. Welsh-Bohmer, K. Wilhelmsen, J. Williamson, T. Wingo, R. Woltjer, C. Wright, Chang-En Yu, Lei Yu, Y. Saba, A. Pilotto, M. Bullido, O. Peters, P. Crane, D. Bennett, P. Bosco, E. Coto, V. Boccardi, P. D. De Jager, A. Lleó, N. Warner, O. Lopez, M. Ingelsson, P. Deloukas, Carlos Cruchaga, C. Graff, R. Gwilliam, M. Fornage, A. Goate, P. Sánchez-Juan, P. Kehoe, N. Amin, N. Ertekin-Taner, C. Berr, S. Debette, S. Love, L. Launer, S. Younkin, J. Dartigues, C. Corcoran, M. Ikram, D. Dickson, G. Nicolas, D. Campion, J. Tschanz, H. Schmidt, H. Hakonarson, J. Clarimón, R. Munger, R. Schmidt, L. Farrer, C. van Broeckhoven, Michael C. O’Donovan, A. Destefano, L. Jones, J. Haines, J. Deleuze, M. Owen, V. Gudnason, R. Mayeux, V. Escott-Price, B. Psaty, A. Ramírez, Li-San Wang, A. Ruiz, C. V. van Duijn, P. Holmans, S. Seshadri, Julie Williams, P. Amouyel, G. Schellenberg, J. Lambert, M. Pericak-Vance +467 moresemanticscholar +1 more sourceCARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes
Advanced Science, EarlyView.This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis. Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang +12 morewiley +1 more sourceGenome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
Nature Genetics, 2019 I. Jansen, J. Savage, Kyoko Watanabe, J. Bryois, Dylan M. Williams, S. Steinberg, J. Sealock, I. Karlsson, S. Hägg, L. Athanasiu, N. Voyle, P. Proitsi, Aree Witoelar, Sven Stringer, D. Aarsland, I. S. Almdahl, Fred Andersen, S. Bergh, F. Bettella, Sigurbjorn Bjornsson, Anne Brækhus, G. Bråthen, C. D. de Leeuw, R. Desikan, S. Djurovic, L. Dumitrescu, T. Fladby, T. Hohman, P. Jonsson, S. Kiddle, A. Rongve, I. Saltvedt, S. Sando, G. Selbæk, M. Shoai, N. Skene, J. Snaedal, E. Stordal, I. Ulstein, Yunpeng Wang, L. White, J. Hardy, J. Hjerling-Leffler, P. Sullivan, W. M. van der Flier, R. Dobson, L. Davis, H. Stefánsson, K. Stefánsson, N. Pedersen, S. Ripke, O. Andreassen, D. Posthuma +52 moresemanticscholar +1 more sourceSingle‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney
Advanced Science, EarlyView.LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai +11 morewiley +1 more sourceCorrection: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade
Molecular NeurodegenerationErica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorito +12 moredoaj +1 more source
