Results 101 to 110 of about 530,865 (344)

Immunomodulation With Local, Sustained Delivery of Pituitary Adenylate Cyclase Activating Polypeptide Results in Improved Functional Recovery in Stroke‐Injured Mice

Advanced Healthcare Materials, EarlyView.
The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho, David Xinzheyang Li, Hong Cui, Dania Akbar, Ricky Siu, Cindi M. Morshead, David Chatenet, Molly S. Shoichet   +7 more
wiley   +1 more source

Review of Postgraduate Dissertations on Alzheimer's Patients in Nursing Care

Yaşlı Sorunları Araştırma Dergisi
Increasingly, health problems have started to occur in the increasing elderly population. The physical and psychological problems that occur with aging have brought the search for new care and treatment methods to the agenda, and with the increase in ...
Fadime Toru
doaj   +1 more source

Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type. [PDF]

, 1984
P A Barford, J.A. Blair, C. Eggar, C.G.B. Hamon, C. Morar, Susan B. Whitburn   +5 more
openalex   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies

Beilstein Journal of Organic Chemistry
The ongoing quest to discover effective treatments for diseases remains a significant challenge for the scientific community. Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling the rapid generation of ...
Lucía Campos-Prieto, Aitor García-Rey, Eddy Sotelo, Ana Mallo-Abreu   +3 more
doaj   +1 more source

ADVANCEMENTS IN ALZHEIMER’S DIAGNOSIS THROUGH MRI USING BAYESIAN CONVOLUTIONAL NEURAL NETWORKS AND VARIATIONAL INFERENCE

Barekeng
Alzheimer’s disease is one of the brain disorders that can be deadly in older. The disease is less treated and less recognized, but Alzheimer’s disease is now a significant public health problem.
Alifia Ardha Nareswari, Dina Tri Utari
doaj   +1 more source

Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes. [PDF]

, 1986
Margaret Haugh, A. Probst, J. Ulrich, J. Kahn, Brian H. Anderton   +4 more
openalex   +1 more source

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source

A experiência pública do Alzheimer no YouTube: competências midiáticas como motores de aprendizagens sociais no canal O Bom do Alzheimer

Intexto
Este artigo investiga de que maneira a experiência midiatizada no canal Francisquinha Alves - O Bom do Alzheimer do YouTube contribui para o desenvolvimento de aprendizagens sociais, a partir da mobilização de competências midiáticas.
Adriana Helena de Almeida Freitas, Rennan Lanna Martins Mafra   +1 more
doaj   +1 more source

Immunocytochemical properties of Alzheimer straight filaments [PDF]

, 1987
George Perry, Paul Mulvihill, Valeria Manetto, L. Autilio‐Gambetti, P. Gambetti   +4 more
openalex   +1 more source