Results 131 to 140 of about 461,295 (348)

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Enhanced Strength and Corrosion Resistance of Ti‐13Nb‐12Ta‐10Zr‐4Sn Alloy by Aging Treatment

Advanced Engineering Materials, EarlyView.
This work systematically investigates the effect of aging treatment on mechanical properties and corrosion behavior of vacuum arc‐melted Ti‐13Nb‐12Ta‐10Zr‐4Sn alloy. Owing to the increased α″ martensite, strength and corrosion resistance were significantly enhanced by aging treatment.
Yuhua Li, Rong Zhao, Qian Zhang, Haojie Wang, Yujing Liu, Lai‐Chang Zhang   +5 more
wiley   +1 more source

Examination of an Imaging Method in Early Alzheimer Disease Diagnosis Support System (VSRAD)

, 2006
Masami Goto, Shigeki Aoki, Osamu Abe, T. Masumoto, Yasushi Watanabe, Yoshiroh Satake, Katsuji Nishida, Kenji Ino, Keiichi Yano, Kyohhito Iida, K. Mima, Kuni Ohtomo   +11 more
openalex   +2 more sources

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Dementia in MS complicated by coexistent Alzheimer disease [PDF]

, 2014
Eoin P. Flanagan, David S. Knopman, B. Mark Keegan   +2 more
openalex   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

A study on the engagement of mild to moderate dementia Alzheimer disease patients to different types of exercises in a series of cognitive stimulation sessions

, 2019
I Sánchez García
openalex   +1 more source

Age-dependent white matter inflammation and cognitive impairment in the TgAPP21 rat model of Alzheimer disease [PDF]

, 2018
M Brodsky, S Anderson, C Murchison, T Chen, Z Mirzadeh, F Ponce, T Aziz, M Hariz, T Chen, Z Mirzadeh, K Chapple, M Brodsky, S Anderson, C Murchison, C Carroll, R Scott, L Davies, T Aziz, A Fytagoridis, M strm, J Samuelsson, P Blomstedt, M Brodsky, S Anderson, C Murchison, E Mulroy, N Robertson, L Macdonald, A Bok, M Simpson, T Wachter, A Minguez-Castellanos, F Valldeoriola, J Herzog, H Stoevelaar, Z Mirzadeh, K Chapple, M Lambert, A Trster, A Levit, B Allman, R Nagalingam, V Hachinski, S Whitehead   +43 more
openalex   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

GOIZ ZAINDU study: a FINGER-like multidomain lifestyle intervention feasibility randomized trial to prevent dementia in Southern Europe

Alzheimer’s Research & Therapy
Background GOIZ ZAINDU (“caring early” in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) methodology to the Basque population and evaluate the feasibility and adherence ...
Mikel Tainta, Mirian Ecay-Torres, Maria de Arriba, Myriam Barandiaran, Ane Otaegui-Arrazola, Ane Iriondo, Maite Garcia-Sebastian, Ainara Estanga, Jon Saldias, Montserrat Clerigue, Alazne Gabilondo, Naia Ros, Justo Mugica, Aitziber Barandiaran, Francesca Mangialasche, Miia Kivipelto, Arantzazu Arrospide, Javier Mar, Pablo Martinez-Lage, on behalf of the GOIZ ZAINDU study group   +19 more
doaj   +1 more source