Results 141 to 150 of about 163,010 (261)

Top five Alzheimer Disease trial eligibility criteria favor men compared to women in a clinic-based cohort. [PDF]

J Prev Alzheimers Dis
Exalto LG, Syaziyah SS, Fang XT, Prins ND, Sikkes SAM, van der Flier WM, Vijverberg EGB, Lim YMF.   +7 more
europepmc   +1 more source

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

Alzheimer Disease [PDF]

Disease-a-Month, 2010
Rudy J, Castellani, Raj K, Rolston, Mark A, Smith   +2 more
openaire   +2 more sources

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Longitudinal Change in Blood-Based Biomarkers and the Association With MRI-Measured Neurodegeneration in Cognitively Unimpaired Individuals. [PDF]

Neurology
Trieu C, Dicks E, de Leeuw D, de Wit KDM, Van Leeuwenstijn MSSA, Schlüter LM, Boonkamp L, Barkhof F, Ten Kate M, van de Giessen E, Van Der Flier WM, Van Harten AC, Teunissen CE.   +12 more
europepmc   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

MusicAlzheimer: AI-Powered, Culturally Tailored Digital Music Therapy Prototype for Alzheimer Disease Care. [PDF]

JMIR Form Res
Yang S, Zhang DY, Zhang M, Yang H, Ma Y.
europepmc   +1 more source

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source

Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic. [PDF]

Neurology
Groot C, Calandri IL, Bader I, Bocancea DI, de Bruin H, Carrigan M, Collij LE, Duits FH, Kamps S, de Koning LA, Lemstra AW, Mastenbroek SE, Rikken RM, van Tol BGJ, Vermeiren MR, Wesseling A, Xia Y, Teunissen CE, van de Giessen E, Barkhof F, Jonkman LE, de Boer C, Rozemuller AJ, Leeuwis AE, van der Vlies AE, Tijms BM, van der Flier WM, Pijnenburg YAL, Coomans EM, Ossenkoppele R.   +29 more
europepmc   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source