Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles [PDF]
Nature Communications, 2022 The tau protein in Alzheimer’s disease contains two isoforms. Using solid-state NMR and seeded growth of isotopically labeled tau, here the authors determined that the two isoforms mix fluently on the molecular level to propagate the AD tau structure.
Aurelio J. Dregni +6 more
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Aluminum and Tau in Neurofibrillary Tangles in Familial Alzheimer’s Disease [PDF]
Journal of Alzheimer's Disease Reports, 2021 Background: Familial Alzheimer’s disease (fAD) is driven by genetic predispositions affecting the expression and metabolism of the amyloid-β protein precursor.
Matthew John Mold +3 more
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Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification [PDF]
Psychiatry and Clinical Neurosciences, 2009 Aims: In this study, the appearance and distribution of neurofibrillary tangles (NFT) in diffuse neurofibrillary tangles with calcification (DNTC) were investigated neuropathologically in order to elucidate the detailed distribution pattern in this disease.Methods: The distribution of NFT in six cases neuropathologically diagnosed as DNTC (two men ...
Norio Ozaki, Katsuyuki Ukai
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Toward a generalizable machine learning workflow for neurodegenerative disease staging with focus on neurofibrillary tangles [PDF]
Acta Neuropathologica Communications, 2023 Machine learning (ML) has increasingly been used to assist and expand current practices in neuropathology. However, generating large imaging datasets with quality labels is challenging in fields which demand high levels of expertise. Further complicating
Juan C. Vizcarra +11 more
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Vitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer’s disease [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Vitamin E may have beneficial effects on oxidative stress and Aβ-associated reactive oxygen species production in Alzheimer’s disease. But, the exact role of vitamin E as a treatment for Alzheimer’s disease pathogenesis still needs to be ...
Mehrdad Jahanshahi +2 more
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In vivo quantification of neurofibrillary tangles with [18F]MK-6240 [PDF]
Alzheimer’s Research & Therapy, 2018 Background Imaging agents capable of quantifying the brain’s tau aggregates will allow a more precise staging of Alzheimer’s disease (AD). The aim of the present study was to examine the in vitro properties as well as the in vivo kinetics, using gold ...
Tharick A. Pascoal +16 more
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Overview of Proteomic Analysis of Amyloid Plaques and Neurofibrillary Tangles in Alzheimer’s Disease [PDF]
BiomoleculesIn this review, we describe the methods used for the extraction and mass spectrometry proteomics analysis of amyloid plaques and neurofibrillary tangles (NFTs), the two primary pathological hallmarks of Alzheimer’s disease (AD).
Amber Grewal +3 more
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Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation [PDF]
Neurobiology of Disease, 2017 Tauopathies are a class of neurodegenerative diseases, including Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, which are associated with the pathological aggregation of tau protein into neurofibrillary tangles (NFT ...
Patrick Reilly +10 more
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Biology, 2022 Efforts have been made to diagnose and predict the course of different neurodegenerative diseases through various imaging techniques. Particularly tauopathies, where the tau polypeptide is a key participant in molecular pathogenesis, have significantly ...
Luis A. Campero-Garcia +5 more
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Fyn depletion ameliorates tauP301L-induced neuropathology
Acta Neuropathologica Communications, 2020 The Src family non-receptor tyrosine kinase Fyn has been implicated in neurodegeneration of Alzheimer’s disease through interaction with amyloid β (Aβ). However, the role of Fyn in the pathogenesis of primary tauopathies such as FTDP-17, where Aβ plaques
Guanghao Liu +5 more
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