Results 11 to 20 of about 48,932 (217)
Microbial involvement in Alzheimer disease development and progression
Molecular Neurodegeneration, 2020 Alzheimer disease (AD) is the most prominent form of dementia and the 5th leading cause of death in individuals over 65. AD is a complex disease stemming from genetic, environmental, and lifestyle factors.
Hannah R. Bulgart +3 more
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Aducanumab: A new hope in Alzheimer's disease
Health Sciences Review, 2022 Alzheimer's disease is an insidious, slowly progressive neurodegenerative disease in aged people and the most prevalent form of dementia, characterized by loss of memory, behavioral changes, cognitive deterioration, and loss of functional abilities that ...
Rouchan Ali +2 more
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Neurofibrillary tangles and tau phosphorylation [PDF]
Biochemical Society Symposia, 2001 Neurofibrillary tangles (NFTs) are a characteristic neuropathological lesion of Alzheimer's disease (AD). They are composed of a highly-phosphorylated form of the microtubule-associated protein tau. We are investigating the relationship between NFTs and microtubule stability and how tau phosphorylation and function is affected in transgenic models and ...
Brion, Jean Pierre +9 more
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Cells, 2022 Alzheimer’s disease is the most common neurodegenerative disease, affecting more than 6 million US citizens and representing the most prevalent cause for dementia.
Hesham Essa +4 more
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Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice
Neurobiology of Disease, 2004 Neurofibrillary tangles, insoluble protein deposits composed of filamentous tau aggregates, are neuropathological hallmarks of Alzheimer's disease and familial frontotemporal dementia (FTDP-17).
Luis Pennanen +4 more
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Molecular Neurodegeneration, 2018 Background Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles.
Dong Kyu Kim +7 more
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Effect of Bone Marrow-Derived Mesenchymal Stem Cells on the Hippocampal CA1 Area of Aluminium Chloride-Induced Alzheimer's Disease in Adult Male Albino Rat: A Histological and Immunohistochemical Study [PDF]
The Egyptian Journal of Histology, 2022 Introduction: Alzheimer’s disease (AD) is the commonest cause of dementia among the elderly. Aluminium is a toxic metal that primarily affects the hippocampus.
Eman El-Beltagi +4 more
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International Journal of Food Properties, 2023 The most rampant and complex form of dementia is Alzheimer’s disease (AD) which is characterized by various cognitive deficits and personality abnormalities.
Ayomide Victor Atoki +3 more
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Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter
Folia Neuropathologica, 2016 Lhermitte-Duclos disease (LDD), a disorder first described by French physicians Lhermitte and Duclos in 1920 [25], is a benign, slow growing dysplastic gangliocytoma of the cerebellum, characterized by replacement of the granule cell layer by abnormal ...
Daniel Rusiecki, Boleslaw Lach
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Tau protein binds to the P53 E3 ubiquitin ligase MDM2
Scientific Reports, 2023 Tau gene mutations cause a progressive dementia and neurotoxic Tau forms deposited in neurofibrillary tangles are hallmarks of neurodegenerative tauopathies. Loss of non-canonical Tau functions may contribute to disease.
Martina Sola +8 more
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