Results 21 to 30 of about 48,932 (217)
Hippocampal Changes in Down’s Syndrome
Pediatric Neurology Briefs, 1995 Semiquantitative scales and quantitative computerized image analyses were used to determine the neurofibrillary tangle formation and AB amyloid deposition in the hippocampal formation and inferior temporal gyrus in 36 Down’s syndrome cases, aged 4 to 73 ...
J Gordon Millichap
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The Wnt/β-catenin signaling pathway affects the distribution of cytoskeletal proteins in Aβ treated PC12 cells [PDF]
Journal of Integrative Neuroscience, 2019 Alzheimer’s disease is pathologically characterized by the presence of senile plaques and neurofibrillary tangles in the central nervous system. Amyloid β-protein is toxic to neurons and induces phosphorylation of Tau protein, which accumulates in paired
Zhifeng Tian, Xiaoling Zhang, Zhijun Zhao, Fuhua Zhang, Tongxing Deng
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A case of diffuse neurofibrillary tangles with calcification [PDF]
Psychiatry and Clinical Neurosciences, 2002 Abstract We report a 79‐year‐old female with atypical senile dementia with Fahr‐type calcification. The patient started to show memory disturbance at the age of 75 years, followed by visual hallucination, stereotypy, personality changes such as irritability, aggression and disinhibition.
Kosuke, Narita +6 more
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Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures
Neurobiology of Disease, 2008 Hyperphosphorylated tau protein is a major component of neurofibrillary tangles, a prominent intracellular hallmark of Alzheimer's disease. Both hyperphosphorylated tau and neurofibrillary tangles have been shown to correlate with dementia in Alzheimer's
Carolyn A. Rankin +2 more
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Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
Molecular Neurodegeneration, 2008 Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of amyloid-β plaques, neuronal loss, and inflammation.
Castellani Rudy J +6 more
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Frontiers in Neuroscience, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative condition characterized by tau pathology and accumulations of neurofibrillary tangles (NFTs) along with amyloid-beta (Aβ).
Musa O. Iliyasu +3 more
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Frontiers in Cell and Developmental Biology, 2022 Reduced cognition in the elderly is associated with low levels of plasmalogens and high levels of lipid rafts, amyloid plaques, and neurofibrillary tangles in the temporal cortex.
Dayan B. Goodenowe, Vijitha Senanayake
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Synaptic tau: A pathological or physiological phenomenon?
Acta Neuropathologica Communications, 2021 In this review, we discuss the synaptic aspects of Tau pathology occurring during Alzheimer’s disease (AD) and how this may relate to memory impairment, a major hallmark of AD.
Miranda Robbins +2 more
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Cell Reports, 2019 Summary: In Alzheimer’s disease (AD), spliceosomal proteins with critical roles in RNA processing aberrantly aggregate and mislocalize to Tau neurofibrillary tangles.
Yi-Chen Hsieh +13 more
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IBRO Reports, 2018 Hormesis is a dose response phenomenon of cells and organisms to various types of stressors. Mild stress stimulates prosurvival pathways and makes the cells adaptive to stressful conditions.
Narayan R. Mane +2 more
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