Results 161 to 170 of about 530,865 (344)
The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Alzheimer's & Dementia, 2011 M. Albert, S. DeKosky, D. Dickson, B. Dubois, H. Feldman, Nick C Fox, A. Gamst, D. Holtzman, W. Jagust, R. Petersen, P. Snyder, M. Carrillo, B. Thies, C. Phelps +13 moresemanticscholar +1 more sourceLecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice
Advanced Science, EarlyView.This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.Xianyun Wang, Dajun Li, Xiao Ying Li, Weizhao Lu, Huini Ding, Chengyan Qi, Xuan Wang, Jing Shen, Yafei Chi, Tiantian Li, Michelle M. Dunk, Yu An, Hongmei Huang, Kang Yu, Weili Xu, Rong Xiao, Yuandi Xi +16 morewiley +1 more sourceNAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR
Advanced Science, EarlyView.Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie +16 morewiley +1 more sourceMeta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Nature Genetics, 2013 J. Lambert, C. Ibrahim-Verbaas, D. Harold, A. Naj, R. Sims, C. Bellenguez, G. Jun, A. Destefano, J. Bis, G. Beecham, B. Grenier‐Boley, G. Russo, T. Thornton-Wells, N. Jones, A. Smith, V. Chouraki, C. Thomas, M. Ikram, D. Zélénika, B. Vardarajan, Y. Kamatani, Chiao-Feng Lin, A. Gerrish, H. Schmidt, B. Kunkle, M. Dunstan, A. Ruiz, M. Bihoreau, S. Choi, C. Reitz, F. Pasquier, P. Hollingworth, A. Ramírez, O. Hanon, A. Fitzpatrick, J. Buxbaum, D. Campion, P. Crane, C. Baldwin, T. Becker, V. Gudnason, C. Cruchaga, D. Craig, N. Amin, C. Berr, O. Lopez, P. D. Jager, V. Deramecourt, J. Johnston, D. Evans, S. Lovestone, L. Letenneur, F. Morón, D. Rubinsztein, G. Eiriksdottir, K. Sleegers, A. Goate, N. Fievet, M. Huentelman, M. Gill, K. Brown, M. Kamboh, L. Keller, P. Barberger‐Gateau, B. McGuinness, E. Larson, R. Green, A. Myers, C. Dufouil, S. Todd, D. Wallon, S. Love, E. Rogaeva, J. Gallacher, P. George-Hyslop, J. Clarimón, A. Lleó, A. Bayer, D. Tsuang, Lei Yu, M. Tsolaki, P. Bossù, G. Spalletta, P. Proitsi, J. Collinge, S. Sorbi, F. Sánchez-García, Nick C Fox, J. Hardy, M. Naranjo, P. Bosco, R. Clarke, C. Brayne, D. Galimberti, M. Mancuso, F. Matthews, S. Moebus, P. Mecocci, M. Zompo, W. Maier, H. Hampel, A. Pilotto, M. Bullido, F. Panza, P. Caffarra, B. Nacmias, J. Gilbert, M. Mayhaus, L. Lannfelt, H. Hakonarson, S. Pichler, M. Carrasquillo, M. Ingelsson, D. Beekly, V. Álvarez, F. Zou, O. Valladares, S. Younkin, E. Coto, K. Hamilton-Nelson, W. Gu, C. Razquín, P. Pastor, I. Mateo, M. Owen, K. Faber, P. Jonsson, O. Combarros, M. O’Donovan, L. Cantwell, H. Soininen, D. Blacker, S. Mead, T. Mosley, D. Bennett, T. Harris, L. Fratiglioni, C. Holmes, R. F. Bruijn, P. Passmore, T. Montine, K. Bettens, J. Rotter, A. Brice, K. Morgan, T. Foroud, W. Kukull, D. Hannequin, J. Powell, M. Nalls, K. Ritchie, K. Lunetta, J. Kauwe, E. Boerwinkle, M. Riemenschneider, M. Boada, M. Hiltunen, E. Martin, R. Schmidt, D. Rujescu, Li-San Wang, J. Dartigues, R. Mayeux, C. Tzourio, A. Hofman, M. Nöthen, C. Graff, B. Psaty, L. Jones, J. Haines, P. Holmans, M. Lathrop, M. Pericak-Vance, L. Launer, L. Farrer, C. Duijn, C. Broeckhoven, V. Moskvina, S. Seshadri, Julie Williams, G. Schellenberg, P. Amouyel +181 moresemanticscholar +1 more sourceDevelopment and Validation of Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease
Advanced Science, EarlyView.This study constructs a stacked multimodal machine learning model for nonalcoholic fattly liver disease (NAFLD) by integrating genetic and clinical features, and synthesize an in‐silico quantitative marker (ISNLD) that enables personalized risk stratification for intrahepatic and extrahepatic outcomes of high‐risk individuals of NAFLD.Lushan Xiao, Lin Zeng, Jiaren Wang, Chang Hong, Ziyong Zhang, Chengkai Wu, Hao Cui, Yan Li, Ruining Li, Shengxing Liang, Qijie Deng, Wenyuan Li, Xuejing Zou, Pengcheng Ma, Li Liu +14 morewiley +1 more source
