Results 201 to 210 of about 530,865 (344)

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

, 1990
Anne M. Cataldo, Ralph A. Nixon
openalex   +1 more source

Protein TAU variants present in paired helical filaments (PHFs) of alzheimer brains [PDF]

, 1990
Yannick Gache, F. Ricolfi, Jocelyne Guilleminot, G. Theiss, José I. Núñez   +4 more
openalex   +1 more source

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Science, 2016
Soyon Hong, Victoria F. Beja-Glasser, Bianca M. Nfonoyim, A. Frouin, Shaoming Li, Saranya Ramakrishnan, Katherine M. Merry, Qiaoqiao Shi, A. Rosenthal, B. Barres, C. Lemere, D. Selkoe, B. Stevens   +12 more
semanticscholar   +1 more source

Aging and the Spectral Properties of Brain Hemodynamics

Advanced Science, EarlyView.
As the brain ages, its metabolic demands decline—but not uniformly. Here, spectral slope flattening of resting‐state fMRI signals is proposed as a potential biomarker of pathologic brain aging. A subset of older adults diverges from youthful spectral and metabolic patterns, with changes linked to frontal white matter pathology and regional loss of ...
Ki Yun Park, Abraham Z. Snyder, Manu S. Goyal, Timothy O. Laumann, John J. Lee, Babatunde Adeyemo, Nicholas Metcalf, Andrei G. Vlassenko, Joshua S. Shimony, Eric C. Leuthardt   +9 more
wiley   +1 more source

Real-world health care costs and resource utilization associated with mild cognitive impairment in the United States: A retrospective cohort study of commercial and Medicare data. [PDF]

J Manag Care Spec Pharm
Frech FH, Li G, Juday TR, Ding Y, Mattke S, Khachaturian AS, Rosenberg AS, Ndiba-Markey C, Rava A, Batrla R, De Santi S, Hampel H.   +11 more
europepmc   +1 more source

Stable intrachain and interchain complexes of neurofilament peptides: a putative link between Al3+ and Alzheimer disease.

, 1994
M. Hollósi, Ziyan Shen, A Perczel, Gerald D. Fasman   +3 more
openalex   +1 more source

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

Trends in the Prevalence and Development of Alzheimer's Disease Among the Elderly Chinese Population: A Systematic Review. [PDF]

Rev Neurol
Han GZ, Liang ZH, Guo LY, Liu MM.
europepmc   +1 more source

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

, 1992
Gregg L. Caporaso, Sam Gandy, Joseph D. Buxbaum, Paul Greengard   +3 more
openalex   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source