Results 251 to 260 of about 530,865 (344)

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source

Non-age Related Differences in Thrombin Responses by Platelets from Male Patients with Advanced Alzheimer′s Disease

, 1993
Theresa A. Davies, Richard E. Fine, R. Johnson, C.A Levesque, Wayne Rathbun, Kurt F Seetoo, Sally J. Smith, G. Strohmeier, L. Volicer, Laurent Delva, Elizabeth R. Simons   +10 more
openalex   +1 more source

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

Cholinergic Basis for Alzheimer Therapy

, 1991
Robert E. Becker, Mario Giacobini
openalex   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source

Towards a national registry for Alzheimer's disease and related dementias: rationale, design, and initial observations of the ABOARD cohort. [PDF]

Alzheimers Res Ther
de Boer C, Rhodius-Meester HFM, van der Landen SM, Claassen J, de Haan R, Papma JM, Seelaar H, Kloppenburg-Lagendijk M, van Munster B, de Vugt M, Arts D, Blom M, de Rijke TJ, Beusink M, Huijsman R, van Veen EB, van Harten A, Vijverberg J, Zwan M, Mutsaerts HJ, van der Lee SJ, van der Flier WM.   +21 more
europepmc   +1 more source

Quantitfication of d-aspartate in normal and Alzheimer brains

, 1992
G. H. Fisher, Antimo D’Aniello, Amedeo Vetere, Gregory P. Cusano, Mirtha Chávez, Leonard Petrucelli   +5 more
openalex   +1 more source

Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients

Advanced Science, EarlyView.
A novel RBC indicator, ESI, is better than the traditional RBC indicators and is associated with CHF prevalence and in‐hospital death. RBC membrane lipidomics, Cer 18:0;O2/16:0, and LPE 18:0, are associated with plasma volume overload and MACE in CHF patients, but these plasma lipids could not.
Lin Zhang, Xiangqin Ou, Jingyi Lin, Xiaofei Luo, Jiashun Zhou, Xingyue Zhou, Peihua Zhao, Li Liu, Ziran Zhao, Ying Zhou, Guanwei Fan, Lifeng Han, Xiumei Gao   +12 more
wiley   +1 more source

Erratum for: MRI-based Deep Learning Assessment of Amyloid, Tau, and Neurodegeneration Biomarker Status across the Alzheimer Disease Spectrum. [PDF]

Radiology
Lew CO, Zhou L, Mazurowski MA, Doraiswamy PM, Petrella JR, Alzheimer’s Disease Neuroimaging Initiative.   +5 more
europepmc   +1 more source

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

Advanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan, Yunxuan Wang, Xufan Deng, Shiyu Wu, Yifan Pan, Jun Du, Mei Yu, Bo Liu, Huimei Wang, Zhengyu Zhang, Jinghong Chen, Shuifa Chen, Yizheng Wang, Tara Walker, Perry Bartlett, Jun Ju, Sheng‐Tao Hou   +16 more
wiley   +1 more source