Results 271 to 280 of about 530,865 (344)

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

Alzheimer disease-associated tau post-translational modification mimics impact tau propagation and uptake. [PDF]

J Neuropathol Exp Neurol
Dickson JR, Sobolewski RGR, Fernandes AR, Cooper JM, Fan Z, Chung M, Donahue C, Oakley DH, Strickland DK, Hyman BT.   +9 more
europepmc   +1 more source

A Systematic Computational Framework for Practical Identifiability Analysis in Mathematical Models Arising from Biology

Advanced Science, EarlyView.
A systematic computational framework is developed for practical identifiability analysis in biological models. The framework establishes a rigorous definition, introduces efficient coordinate‐based identifiability metrics, and proposes novel regularization strategies.
Shun Wang, Wenrui Hao
wiley   +1 more source

Enhancing participation of historically minoritized groups in Alzheimer disease and related dementias research: National Conference Report. [PDF]

Alzheimers Dement
Mozersky J, Dimtsu Assfaw A, Balls Berry JE, Moulder KL, Denny A, Aranda M, Asthana S, Babulal G, Berry B, Boyd A, Buchwald D, Croff R, Flatt J, Gabel M, Gleason CE, Glover CM, Green-Harris G, Hudson D, Jackson J, Johnson DK, Medina L, Mendez S, O'Bryant S, Park VT, Parker MW, Petty D, Stites SD, Streitz ML, Ushe M, Wilkins CH, Zuelsdorff M, Morris JC.   +31 more
europepmc   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

Cardioprotective Glucose-Lowering Agents and Dementia Risk: A Systematic Review and Meta-Analysis.

JAMA Neurol
Seminer A, Mulihano A, O'Brien C, Krewer F, Costello M, Judge C, O'Donnell M, Reddin C.   +7 more
europepmc   +1 more source

Survival Differences Between Individuals With Typical and Atypical Phenotypes of Alzheimer Disease. [PDF]

Neurology
Bader I, Groot C, Van Der Flier WM, Pijnenburg YAL, Ossenkoppele R.   +4 more
europepmc   +1 more source