Results 271 to 280 of about 9,708,599 (370)

Olfactory dysfunction in Alzheimer’s disease

, 2016
Zou YM, Danfeng Lu, Liu LP, Zhang HH, Zhou YY   +4 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Evaluating Plasma p-tau217 as an Endpoint for Alzheimer Disease Clinical Trials. [PDF]

Neurology
Ferreira PCL, Bellaver B, Povala G, Bauer-Negrini G, Aguzzoli CS, Ferrari-Souza JP, Leffa DT, Soares C, Lussier FZ, Medeiros MS, Felix C, Ruppert E, Rohden F, Borelli WV, Karim HT, Langhough R, Christian BT, Wilson R, Hong CH, Roh HW, Patira R, Tudorascu DL, Zimmer ER, Betthauser TJ, Karikari TK, Snitz BE, Johnson SC, Son SJ, Pascoal TA.   +28 more
europepmc   +1 more source

PEDOT:PSS—A Key Material for Bioelectronics

Advanced Science, EarlyView.
PEDOT:PSS ‐ Poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate ‐ is typically processed from water dispersions to form multifunctional and multidimensional constructs with tunable electronic and ionic conductivity. Throught processing engineering, PEDOT:PSS is intergrated in bioelectronic devices that operate efficiently in physiological conditions
Alan Eduardo Ávila Ramírez, David Pieter van der Laan, Mustafeez Bashir Shah, Liwen Wang, Erica Zeglio, Achilleas Savva   +5 more
wiley   +1 more source

Cognitive impairment and Alzheimer’s disease: Links with oxidative stress and cholesterol metabolism

, 2008
Alejandra Sekler, Jos eacute M Jim eacute nez, Leonel E. Rojo, Edgard Pastene, Patricio Fuentes, et al   +5 more
openalex   +1 more source