Results 261 to 270 of about 362,575 (339)

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility? [PDF]

Clin Chem
Benedet AL, Arslan B, Tan K, Huber H, Pola I, Di Molfetta G, Kvartsberg H, Dolado AO, Janelidze S, Blennow K, Zetterberg H, Hansson O, Rosa-Neto P, Ashton NJ.   +13 more
europepmc   +1 more source

Neuropsychiatric signs and symptoms of Alzheimer\u27s disease: New treatment paradigms [PDF]

, 2017
et al,, Musiek, Erik
core   +1 more source

Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Advanced Science, EarlyView.
Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li, Yue Wang, Xiufang Liang, Mengze Xu, David T. Leong, Pu Chun Ke   +5 more
wiley   +1 more source

Quality Gaps in Online Media Coverage of Antiamyloid Monoclonal Antibodies for Alzheimer Disease.

JAMA Netw Open
Macedo AC, de Lima AG, Miaw ISL, Bizzi IH, Balbino JMV, Therriault J, Zimmer ER, Ghezzi P, Rosa-Neto P.   +8 more
europepmc   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease. [PDF]

Neurology
Llibre-Guerra JJ, Lu R, Clarens MF, Liu I, Renton A, Ryan NS, Goate AM, Aguillón D, Allegri RF, Benzinger TLS, Berman S, Chhatwal JP, Chrem Mendez P, Vigo G, Cruchaga C, Day GS, Farlow MR, Fox NC, Gordon BA, Hassenstab J, Huey ED, Ibanez L, Ikeuchi T, Jucker M, Lee JH, Levey AI, Levin J, Niimi Y, Perrin RJ, Rosa-Neto P, Sánchez-Valle R, Schofield PR, Wang G, Li Y, Xiong C, Morris JC, Karch C, Daniels AJ, McDade E, Bateman RJ.   +39 more
europepmc   +1 more source

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source