Results 81 to 90 of about 9,708,599 (370)

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia

Nature
Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1.
Michael Haney, Róbert Pálovics, C. Munson, Chris M. Long, Patrik K. Johansson, Oscar Yip, Wentao Dong, Eshaan S. Rawat, Elizabeth West, J. Schlachetzki, A. Tsai, Ian H. Guldner, Bhawika S. Lamichhane, Amanda Smith, N. Schaum, Kruti Calcuttawala, Andrew Shin, Yung-Hua Wang, Chengzhong Wang, Nicole Koutsodendris, G. Serrano, T. Beach, Eric M. Reiman, Christopher K. Glass, Monther Abu-Remaileh, Annika Enejder, Yadong Huang, Tony Wyss-Coray   +27 more
semanticscholar   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Comfort Care in Advanced Alzheimer\u27s Disease [PDF]

, 2005
No abstract ...
Maxwell, Terri, Parks, Susan
core   +1 more source

The value of hippocampal and temporal horn volumes and rates of change in predicting future conversion to AD. [PDF]

, 2012
Hippocampal pathology occurs early in Alzheimer disease (AD), and atrophy, measured by volumes and volume changes, may predict which subjects will develop AD.
ADNI investigators, Barnes, Josephine, Bartlett, Jonathan W, Leung, Kelvin K, Macdonald, Kate E, Ourselin, Sebastien   +5 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Perusinis II. Fall: Der Alzheimer Patient R.M. Geschichte, Genealogie und Genetik eines psychiatriehistorischen Falls [PDF]

, 2012
1.American Journal of Alzheimer`s Disease and Other Dementias: 2010; 25:189-192 100th anniversary of PERUSINI`S SECOND CASE: PATIENT RM and his KINDRED
Braun, Birgit
core  

Brain amyloid in preclinical Alzheimer\u27s disease is associated with increased driving risk [PDF]

, 2016
INTRODUCTION: Postmortem studies suggest that fibrillar brain amyloid places people at higher risk for hazardous driving in the preclinical stage of Alzheimer's disease (AD). METHODS: We administered driving questionnaires to 104 older drivers (19 AD, 24
Bernier, Justine N, Carr, David B, Jones, Richard N, Noto, Richard B, Ott, Brian R, Roe, Catherine M, Snyder, Peter J, Yoo, Don C   +7 more
core   +2 more sources

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice

Molecular Neurodegeneration
Background Pathogenic tau accumulation drives neurodegeneration in Alzheimer’s disease (AD). Enhancing the aging brain’s resilience to tau pathology would lead to novel therapeutic strategies.
Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Jingjie Zhu, Nessa Foxe, Winston Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Tark Patel, Sue-Ann Mok, Won-min Song, Bin Zhang, Shiaoching Gong, Qin Ma, Hongjun Fu, Li Gan, Wenjie Luo   +21 more
doaj   +1 more source