Results 121 to 130 of about 8,951,121 (298)

Zonificación de procesos de ladera e inundaciones a partir de un análisis morfométrico en la cuenca alta del río General, Costa Rica

Investigaciones Geográficas, 2019
En países tropicales como Costa Rica, la incidencia de procesos de ladera e inundaciones están condicionados por las lluvias extraordinarias, el tipo de sustrato y su grado de meteorización, la sismicidad, la morfología y la inclinación del terreno.
Adolfo Quesada Román, José Juan Zamorano Orozco   +1 more
doaj   +1 more source

ADMINISTRAÇÃO PÚBLICA NO CONTEXTO INTERNACIONAL: A PARTICIPAÇÃO NO 5º CADAPi (CURSO DE ALTA DIREÇÃO EM ADMINISTRAÇÃO EM ADMINISTRAÇÃO PÚBLICA – INTERNACIONAL) , OEIRAS - PORTUGAL [PDF]

, 2011
A participação no 5º CADAPi proporcionou-me o desenvolvimento de novas competências, desde agradecer todos os dias pela interculturalidade presenciada e vivida, além de reforçar os conceitos tão caros para a busca da eficiencia em administração pública ...
Melo, Ana Lucia Aguiar
core  

Tourist spaces and tourism policy in Spain and Portugal [PDF]

, 2015
Advances in Cultura, Tourism and Hospitality Research;10, 235-249This study analyses the relationship between the development of the tourism policy of Spain and Portugal and their effects on regional imbalances. Despite the proximity of the two countries
Antón S., Apostolopoulos Y., Blázquez M., Bote V., Brunet P., Cals J., Casanova L., Cunha L., Cunha L., Edgell D. L., Esteve R., Hall C. M., Hall C. M., Hall D., Lea J., Lickorish L. J., Martins J., Martins J., Monfort V., Pearce D., Ramón B., Swarbrooke J., Vallejo R., Velasco M., Vera J. F., Vera J. F., Vera J. F., Williams A. M., Williams A. M.   +28 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Radical, reformist and aborted liberalism: origins of national regimes in Central America

América Latina Hoy, 2011
During the twentieth century, the countries of Central America were characterized by remarkably different political regimes: military-authoritarianism in Guatemala and El Salvador, progressive democracy in Costa Rica and traditional-authoritarianism in ...
James MAHONEY
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

“Vías de penetración de la masonería en el Caribe”

REHMLAC, 2009
La introducción y desarrollo de la Fr ancmasonería en América fue un claro refl ejo y transposición de la situación de la masonería en la Europa del siglo XVIII y comienzo s del XIX.
José Antonio Ferrer Benimeli
doaj  

Abejas, apicultura y el nuevo mundo [PDF]

, 1992
In the New World, some stingless bees were kept by the native population. In Central America, maya beekeepers worked with Mellipona beecheii, in Yucatan and adjacent regions. The arrival in North America of the first beehives was in 1691 and it were sent
Bustos Ruiz, M., Flores Serrano, J.M., Padilla-Alvarez, F., Puerta Puerta, F.   +3 more
core  

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source