Results 11 to 20 of about 5,813 (114)
CerM and Its Antagonist CerN Are New Components of the Quorum Sensing System in Cereibacter sphaeroides, Signaling to the CckA/ChpT/CtrA System. [PDF]
MicrobiologyopenThe quorum sensing (QS) system of Cereibacter sphaeroides includes six LuxR homologs and one acylhomoserine lactone synthase homolog. Two LuxR homologs, CerM and CerN, are involved in regulating the expression of ctrA, which is part of the CckA/ChpT/CtrA two‐component system that controls flagellar motility.
Hernández-Valle J +3 more
europepmc +2 more sources
Machine learning methods for developments of binding kinetic models in predicting protein-ligand dissociation rate constants. [PDF]
Smart Mol, 2023 This paper develops a variety of binding kinetic models for predicting dissociation rate constants using eight machine learning methods, which are tested by two case studies involving the HSP90 and RIP1 kinase inhibitors. Both regression results of the two case studies indicate that the Bayesian neural network model has the state‐of‐the‐art prediction ...
Zhao Y, Liu Q, Du J, Meng Q, Zhang L.
europepmc +2 more sources
Phytofabricated Silver Nanoparticles From <i>Vaccinium arctostaphylos</i> L.: Anticancer Activity Against Breast Cancer Cells via Apoptosis Induction and Growth Suppression. [PDF]
Food Sci NutrThis study demonstrates that phytofabricated silver nanoparticles (VACAgNPs) from Vaccinium arctostaphylos L. exhibit significant anticancer activity against breast cancer cells, inducing apoptosis and suppressing growth in both hormone‐responsive (MCF‐7) and triple‐negative (4T1, MDA‐MB‐231) subtypes. The nanoparticles enhanced reactive oxygen species
Soleimani N +3 more
europepmc +2 more sources
Imaging of KCa 3.1 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes. [PDF]
ChemMedChem, 2023 Highly aggressive human tumors use the Ca2+ activated K+ channel KCa3.1. for key processes of the metastatic cascade. Imaging of the KCa3.1 channel in vitro and in vivo represents a valuable diagnostic and prognostic tool. A 18‐fluorine labeled senicapoc‐based PET tracer showed promising imaging properties in vivo.
Thale I +9 more
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
Journal of Flood Risk Management, Volume 16, Issue 3, September 2023., 2023 Abstract Around 45% of natural hazards reported worldwide are related to floods, and current indications show that exposure to floods and inherent losses will keep escalating. Historic centres are particularly vulnerable in this context due to the structural and material characteristics of the buildings and because they embrace social and cultural ...
Lucy Davis +6 more
wiley +1 more source
Infant Mental Health Journal: Infancy and Early Childhood, Volume 43, Issue 3, Page 455-473, May 2022., 2022 Abstract Research points to the significant impact of maternal distress on the parent‐infant relationship and infant development. The Newborn Behavioral Observations (NBO) is a brief intervention supporting the infant, the parent and their relationship.
Susan Nicolson +2 more
wiley +1 more source
Journal of Chemistry, Volume 2022, Issue 1, 2022., 2022 Fungal infections, including those caused by Candida spp., are recognized in immunocompromised individuals for their high rates of morbidity and mortality. Microorganism resistance to conventional drugs compromises treatment effectiveness and yet also reveals the need to develop new drugs.
Allana B. S. Duarte +5 more
wiley +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
British Journal of Pharmacology, Volume 178, Issue S1, Page S27-S156, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +154 more
wiley +1 more source
Proximity across the distant worlds of university–industry collaborations
Papers in Regional Science, Volume 100, Issue 3, Page 689-711, June 2021., 2021 Abstract This paper examines the extent to which firms perceive different dimensions of proximity to be important for the formation of their interactions with universities. Furthermore, it investigates whether the importance of the different types of proximities varies depending on the type of interaction—be it about knowledge exploration, knowledge ...
Utku Ali Rıza Alpaydın +1 more
wiley +1 more source