Results 101 to 110 of about 21,777 (202)

Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression. [PDF]

, 2020
Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by epigenetics, as retinoblastoma genomes are stable, but the mechanism(s) that ...
Benavente, Claudia A, Gu, Yijun, Mehta, Aditi, Spitale, Robert C, Suh, Susie, Wang, Jingtian, Wu, Jie, Wu, Stephanie C, Zocchi, Loredana   +8 more
core  

Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina

Cell Reports
Summary: The retina is exquisitely patterned, with neuronal somata positioned at regular intervals to completely sample the visual field. Here, we show that phosphatase and tensin homolog (Pten) controls starburst amacrine cell spacing by modulating ...
Yacine Touahri, Joseph Hanna, Nobuhiko Tachibana, Satoshi Okawa, Hedy Liu, Luke Ajay David, Thomas Olender, Lakshmy Vasan, Alissa Pak, Dhruv Nimesh Mehta, Vorapin Chinchalongporn, Anjali Balakrishnan, Robert Cantrup, Rajiv Dixit, Pierre Mattar, Fermisk Saleh, Yaroslav Ilnytskyy, Monzur Murshed, Paul E. Mains, Igor Kovalchuk, Julie L. Lefebvre, Hon S. Leong, Michel Cayouette, Chao Wang, Antonio del Sol, Marjorie Brand, Benjamin E. Reese, Carol Schuurmans   +27 more
doaj   +1 more source

Loss of photoreceptors results in upregulation of synaptic proteins in bipolar cells and amacrine cells.

PLoS ONE, 2014
Deafferentation is known to cause significant changes in the postsynaptic neurons in the central nervous system. Loss of photoreceptors, for instance, results in remarkable morphological and physiological changes in bipolar cells and horizontal cells ...
Sushma Dagar, Saumya Nagar, Manvi Goel, Pitchaiah Cherukuri, Narender K Dhingra   +4 more
doaj   +1 more source

Changes in glycinergic neurotransmission alter mammalian retinal information processing

Frontiers in Molecular Neuroscience
Glycine, along with GABA, constitutes the major inhibitory neurotransmitter in the central nervous system. In the retina, glycinergic neurotransmission is primarily used by amacrine cells that are involved in the lateral processing of visual stimuli in ...
Anneka Joachimsthaler, Anneka Joachimsthaler, Katharina Hauf, Katharina Hauf, Anja Armbruster, Shiri Zayit-Soudry, Efrat Naaman, Ido Perlman, Rina Leibu, Alina Kurolap, Hagit Baris Feldman, Hagit Baris Feldman, Jan Kremers, Jan Kremers, Volker Eulenburg, Volker Eulenburg, Volker Eulenburg   +16 more
doaj   +1 more source

Dendro-dendritic cholinergic excitation controls dendritic spike initiation in retinal ganglion cells

Nature Communications, 2017
Neural computations performed by the retinal microcircuit have been extensively studied. Here the authors report using dendritic recordings that the direction selective responses of retinal ganglion cells are controlled by dendro-dendritic cholinergic ...
A. Brombas, S. Kalita-de Croft, E. J. Cooper-Williams, S. R. Williams   +3 more
doaj   +1 more source

Retinal Neurochemistry

Brain Sciences
The vertebrate retina is a complex neural tissue composed of a repeating array of distinct cell types that communicate through specialized synaptic connections. The neurochemistry underlying these connections reveals the synaptic chemistry, including the
Dominic Man-Kit Lam, George Ayoub
doaj   +1 more source

Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells. [PDF]

Elife, 2023
Gaynes JA, Budoff SA, Grybko MJ, Poleg-Polsky A.   +3 more
europepmc   +1 more source

Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities. [PDF]

, 2010
In mammals, synchronization of the circadian pacemaker in the hypothalamus is achieved through direct input from the eyes conveyed by intrinsically photosensitive retinal ganglion cells (ipRGCs).
Alam, Nazia M, Altimus, Cara M, Arman, A Cyrus, Güler, Ali D, Hattar, Samer, Prusky, Glen T, Sampath, Alapakkam P   +6 more
core  

Correction: Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson's disease patients. [PDF]

Transl Neurodegener, 2023
Sánchez-Sáez X, Ortuño-Lizarán I, Sánchez-Castillo C, Lax P, Cuenca N.   +4 more
europepmc   +1 more source

Layers of inhibitory networks shape receptive field properties of AII amacrine cells. [PDF]

Cell Rep, 2023
Nath A, Grimes WN, Diamond JS.
europepmc   +1 more source