Results 41 to 50 of about 1,187 (168)

THE TOXICOLOGICAL CONSTITUTION OF AMANITA PHALLOIDES [PDF]

Journal of Experimental Medicine, 1906
From the experiments detailed in this paper it may be concluded that Amanita phalloides contains besides phallin, or the hæmolytic principle of Kobert, another body of toxic nature. Phallin is thermolabile, and is destroyed by the action of pepsin and pancreatin. The other toxic body is thermostable and is resistant to pepsin and pancreatin.
openaire   +2 more sources

HEMOPERFUSION IN AMANITA PHALLOİDES POISONING: REPORT OF TWO CASES

Turkish Journal of Nephrology, 2019
Amanita phalloides mushrooms are extremely toxic. Alpha-amanitin is an amatoxin known to produce deleterious effects on the liver and the kidneys, when circulating in the blood.
Osman DÖNMEZ, Merih ÇETİNKAYA, Gönül EMİR   +2 more
doaj  

Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro

Toxins, 2021
Alpha-amanitin (α-AMA) is a cyclic peptide and one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the
Doeun Kim, Sunjoo Kim, Ann-Yae Na, Chang Hwan Sohn, Sangkyu Lee, Hye Suk Lee   +5 more
doaj   +1 more source

Exploring the Substitution of the C21‐OAc Moiety in [11]Cytochalasans: Synthesis and Evaluation of Fluorophore Conjugates

ChemBioChem, Volume 27, Issue 1, January 2026.
Via in silico docking of pyrichalasin H on G‐ and F‐actin, the C21‐OAc moiety is identified as a modifiable site tolerated for actin binding. Fluorescent [11]cytochalasan probes from pyrichalasin H and epoxycytochalasin C are obtained by selective C21‐OAc hydrolysis and acylation.
Mervic D. Kagho, Katharina Schmidt, Aishi Chakrabarti, Marius Karger, Christopher Lambert, Maurice Hauser, Russell J. Cox, Klemens Rottner, Marc Stadler, Theresia E. Stradal, Philipp Klahn   +10 more
wiley   +1 more source

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

A New Conjugation Method Used for the Development of an Immunoassay for the Detection of Amanitin, a Deadly Mushroom Toxin

Toxins, 2018
One of the deadliest mushrooms is the death cap mushroom, Amanita phalloides. The most toxic constituent is α-amanitin, a bicyclic octapeptide, which damages the liver and kidneys.
Candace S. Bever, Bogdan Barnych, Robert Hnasko, Luisa W. Cheng, Larry H. Stanker   +4 more
doaj   +1 more source

Molecular mechanisms of hotspot variants in cytoskeletal β‐actin associated with Baraitser–Winter syndrome

The FEBS Journal, Volume 292, Issue 18, Page 4898-4917, September 2025.
Variants at position R196 in cytoskeletal β‐actin are the most common variants associated with Baraitser–Winter cerebrofrontofacial syndrome and result in craniofacial anomalies and neurodevelopmental disorders, most likely due to neuronal migration defects. This study explores the molecular mechanisms of p.R196 variants using purified proteins.
Johannes N. Greve, Dietmar J. Manstein
wiley   +1 more source

[Poisonings with Amanita phalloides].

Medycyna pracy, 2010
Amanita phalloides is the most dangerous, poisonous mushroom species in our climatic conditions. It is the cause of 90-95% of all deaths due to mushroom poisoning, a-Amanitin, a polymerase RNA II inhibitor, is mainly responsible for the Amanita phalloides toxic property.
Tomasz, Ferenc, Beata, Lukasiewicz, Julita, Ciećwierz, Edward, Kowalczyk   +3 more
openaire   +2 more sources

Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells

Toxins
Amanita phalloides poisonings account for the majority of fatal mushroom poisonings. Recently, we identified hematotoxicity as a relevant aspect of Amanita poisonings. In this study, we investigated the effects of the main toxins of Amanita phalloides, α-
Willemien F. J. Hof, Miranda Visser, Joyce J. de Jong, Marian N. Rajasekar, Jan Jacob Schuringa, Inge A. M. de Graaf, Daan J. Touw, Bart G. J. Dekkers   +7 more
doaj   +1 more source

Tryptophan‐Selective Chemical Modification of Peptides by Thioether‐Mediated Sulfenylation

ChemistryEurope, Volume 3, Issue 3, May 2025.
A thioether‐mediated sulfenylation method based on 4‐fluorophenyl 3‐nitro‐2‐pyridinesulfenate (Npys‐OPh(pF)) is developed for Trp‐selective chemical modification. This sulfenylation proceeds under mild, metal‐free, and weakly acidic conditions and is broadly applicable to the chemical modification of various Trp‐containing peptides as well as the late ...
Hayate Shida, Akihiro Taguchi, Yuma Tokita, Yan Cui, Momoka Sakamaki, Sho Konno, Atsuhiko Taniguchi, Young Sook Yun, Yuuta Fujikawa, Hiroshi Kaneko, Hidemasa Nakaminami, Yoshio Hayashi   +11 more
wiley   +1 more source